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Abstract: The safety of the high-pressure oxygen system in the operation of GE coal water slurry gasification device is crucial! High pressure and concentration pose significant operational risks to both oxygen pipelines and valves. This article focuses on several oxygen accidents and events (such as pipeline explosion, leakage, coal slurry pollution, etc.) that occurred after the coal hydrogen production unit was put into normal production and operation. The root causes were analyzed, and improvement and optimization measures were proposed to effectively ensure the effective and safe operation of the oxygen system. This article mainly reviews and analyzes typical cases that have occurred during the operation process over the years, and summarizes the emergency judgment, operation adjustment, shutdown handling, and accident and event response analysis and improvement measures for past accidents and event handling processes. The pipelines, valves, and related accessories of the oxygen system inherently pose certain potential hazards during production and operation. At the beginning of construction operations, the oxygen system comprehensively monitors pipeline welding and installation, degreasing and passivation, chemical cleaning, analysis and testing, etc. And the acceptance standards for the oxygen system are extremely strict and demanding: it requires the welding oxide to be completely peeled off; Purple light irradiation without blue spots; Camphor slices and sealing test are qualified. At the same time, airtightness and patrol inspection during operation are very important. Only by strictly controlling the safety of the oxygen system can we timely control the occurrence of anomalies and hidden dangers at the source.Abstract: The safety of the high-pressure oxygen system in the operation of GE coal water slurry gasification device is crucial! High pressure and concentration pose significant operational risks to both oxygen pipelines and valves. This article focuses on several oxygen accidents and events (such as pipeline explosion, leakage, coal slurry pollution, etc.) ...Learn More
Abstract: In this study, Irinotecan (ICA) was used as a model drug, and MIL-101(Fe) was used as a drug carrier to load ICA, ICA@MIL-100(Fe) complex was prepared by impregnating adsorption method. A high performance liquid chromatography (HPLC) method was established to determine the content of ICA from ICA@MIL-100(Fe) complex. The established method had good linear relationship, precision, repeatability, stability and sample recovery, and the RSD was less than 2%. Molecular simulation was used to further investigate the site and stability of interaction. Experiment results showed that when the concentration of ICA was 1mg/mL, the mass ratio of drug to carrier was 1:1, the adsorption time was 24 h, the drug loading capacity of ICA by MIL-100(Fe) was (8.88±0.03) %. Molecular simulation experiments showed that when ICA was incorporated into the tetrahedron of MIL-101(Fe), the binding between ICA and MIL-100(Fe) revealed the most stable dominant conformation, which supported the feasibility of MIL-101(Fe) used as a new drug carrier loading ICA.Abstract: In this study, Irinotecan (ICA) was used as a model drug, and MIL-101(Fe) was used as a drug carrier to load ICA, ICA@MIL-100(Fe) complex was prepared by impregnating adsorption method. A high performance liquid chromatography (HPLC) method was established to determine the content of ICA from ICA@MIL-100(Fe) complex. The established method had good...Learn More
Abstract: In this paper, we explore the application of the PBL teaching method with the combination of the OBE concept from Engineering Education Accreditation in the teaching of polymer chemistry. In the process of building a heuristic question bank, the graduation requirements indicator points can serve as a guideline to classify and summarize the questions. In the actual teaching process, it is proved to effectively cultivate students' independent thinking ability and innovative spirit. Taking the teaching key and difficult points in the course of Polymer Chemistry as the breakthrough, this paper explores the application of PB; teaching method. In the practical teachings, we integrated the OBE idea from China Engineering Education Accreditation Association (CEEAA) and classified the teaching problems, according to the instruction of graduation requirements of the course. The practical results show that the PBL teaching method is effective in stimulating students' interest in learning and mobilizing the classroom atmosphere, enhancing the sense of teamwork, helping to cultivate students’ independent thinking ability and innovative spirit, and significantly improving students' overall quality within the limited course hours.Abstract: In this paper, we explore the application of the PBL teaching method with the combination of the OBE concept from Engineering Education Accreditation in the teaching of polymer chemistry. In the process of building a heuristic question bank, the graduation requirements indicator points can serve as a guideline to classify and summarize the question...Learn More
