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Abstract: Anhydrous ethanol 100 mL was measured and a certain amount of tetrabutyl titanate and acetylacetone were added to label as the base solution A, which was mixed evenly under the stirring of a magnetic stirrer. Anhydrous ethanol 50 mL was added with a certain amount of nitric acid and water, mixed evenly and labeled as base solution B. N-doped titanium dioxide films were mixed into liquid B with ammonia as the N source in a certain proportion. The reaction was stirred by a stirrer under the condition of chamber temperature, and the pH value of the basic solution A should be continuously controlled between 3 and 4, and the basic solution B should be slowly added to the basic solution A. After magnetically stirring the prepared sol for 10 min, slowly adding a certain amount of ammonia water, and then continuing to stir for 15 min, N-doped titanium dioxide sol was obtained. The molar ratio of control acetyl acetone, nitric acid, tetrabutyl titanate, water and anhydrous ethanol is = 1:1:5:25:150. The suitable degradation conditions of the films were studied, including calcination time of 50 min, calcination temperature of 450°C, coating layer number of 4, and molar ratio of ammonia water to tetrabutyl titanate of 1:25. The prepared N-doped titanium dioxide sol was plated on the pre-treated substrate by rotating method, dried under natural conditions, calcined in Muffle furnace, kept the furnace temperature at 5°C/min to 450°C, kept constant at 450°C for 50 min, and then cooled to room temperature naturally, and the coating was completed once, and the above coating was repeated four times. N-doped titanium dioxide films prepared were used for photocatalytic degradation of methylene blue.Abstract: Anhydrous ethanol 100 mL was measured and a certain amount of tetrabutyl titanate and acetylacetone were added to label as the base solution A, which was mixed evenly under the stirring of a magnetic stirrer. Anhydrous ethanol 50 mL was added with a certain amount of nitric acid and water, mixed evenly and labeled as base solution B. N-doped titani...Learn More
Abstract: Objective To design and synthesize β-lactam triazole compounds. Methods Using triazole and 6-aminopenicillanic acid as starting materials, a series of β-lactam triazole compounds were synthesized based on the principle of active splicing. The molecular structures were characterized by 1H NMR, 13C NMR and mass spectrometry. The antibacterial activity and the ability to inhibit β-lactamase of the target compounds were then determined. Results Three target compounds not reported in the literature were synthesized. After three batches of repeated experiments, the minimum inhibitory concentration of the compounds was determined: the negative control group showed stable bacterial growth, and the blank control group had no bacterial growth, indicating the validity and reliability of the antibacterial ability of the compounds themselves; the inhibitory effect of the compounds on β-lactamase activity was determined: CX-1 (target compound 1) had potential β-lactamase inhibitory properties, while the structurally similar CX-2 (target compound 2) and CX-3 (target compound 3) had relatively weak effects, but all had inhibitory effects on β-lactamase. Conclusion This study holds significant importance for future research directions. By leveraging the findings from this study, researchers can focus on modifying the molecular structures of these β-lactam triazole compounds to discover new compounds with enhanced antibacterial efficacy and more straightforward synthetic routes.Abstract: Objective To design and synthesize β-lactam triazole compounds. Methods Using triazole and 6-aminopenicillanic acid as starting materials, a series of β-lactam triazole compounds were synthesized based on the principle of active splicing. The molecular structures were characterized by 1H NMR, 13C NMR and mass spectrometry. The antibacterial activit...Learn More
