MIL-101(Fe) as a Drug Carrier of Loading Irinotecan: Experimental and Theoretical Studies
College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
| Abstract: | In this study, Irinotecan (ICA) was used as a model drug, and MIL-101(Fe) was used as a drug carrier to load ICA, ICA@MIL-100(Fe) complex was prepared by impregnating adsorption method. A high performance liquid chromatography (HPLC) method was established to determine the content of ICA from ICA@MIL-100(Fe) complex. The established method had good linear relationship, precision, repeatability, stability and sample recovery, and the RSD was less than 2%. Molecular simulation was used to further investigate the site and stability of interaction. Experiment results showed that when the concentration of ICA was 1mg/mL, the mass ratio of drug to carrier was 1:1, the adsorption time was 24 h, the drug loading capacity of ICA by MIL-100(Fe) was (8.88±0.03) %. Molecular simulation experiments showed that when ICA was incorporated into the tetrahedron of MIL-101(Fe), the binding between ICA and MIL-100(Fe) revealed the most stable dominant conformation, which supported the feasibility of MIL-101(Fe) used as a new drug carrier loading ICA. |
| Keywords: | Irinotecan; MIL-101(Fe); Drug Loading; Molecular Docking |
| DOI: | 10.57237/j.cse.2023.04.002 |
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Received: 31 August 2023
Accepted: 27 October 2023
Published Online: 28 October 2023
References
| [1] | Dai P, Chen S, Wang M, et al. β-Carboline alkaloids from Picrasma quassioides and their 3D-QSAR study on anti-inflammation in LPS-induced RAW 264.7 cells [J]. Fitoterapia, 2023, 166: 105437. |
| [2] | Farouk L, Laroubi A, Aboufatima R, et al. Evaluation of the analgesic effect of alkaloid extract of Peganum harmala L: possible mechanisms involved [J]. Journal of ethno- pharmacology, 2008, 115(3): 449-454. |
| [3] | Wada K, Takaguri A, Kaneda K, et al. Rational design and structure-activity relationship studies reveal new esterified C20-diterpenoid alkaloid analogues active against MCF-7 human breast cancer cells [J]. Journal of Natural Medicines, 2023, 77(2): 276-283. |
| [4] | Zhang J, Hansen L G, Gudich O, et al. A microbial supply chain for production of the anti-cancer drug vinblastine [J]. Nature, 2022, 609(7926): 341-347. |
| [5] | Önal G. Investigation of the electrochemical properties of vinblastine on boron-doped diamond electrode treated with anodic pre-treatment in anionic surfactant medium [J]. Diamond and Related Materials, 2023, 133: 109699. |
| [6] | Alqahtani F Y, Aleanizy F S, El Tahir E, et al. Paclitaxel [J]. Profiles of Drug Substances, Excipients, and Related Methodology, 2019, 44: 205-238. |
| [7] | Mai N X D, Nguyen T H T, Nguyen L H T, et al. Engineering biodegradable periodic mesoporous functionalized-organosilica nanocarriers for efficient paclitaxel delivery [J]. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2023, 656: 130405. |
| [8] | 盛贻林, 李云霞, 俞文榜, 等. 一株喜树内生菌的分离与发酵试验 [J]. 药物生物技术, 2016, 23(05): 390-392. |
| [9] | Fukuda M, Shimada M, Kitazaki T, et al. Phase I study of irinotecan for previously treated lung cancer patients with the UGT1A1*28 or *6 polymorphism: Results of the Lung Oncology Group in Kyushu (LOGIK1004A). Thorac Cancer. 2017, 8(1): 40-45. |
| [10] | 杨建坤, 商亚贞, 刘宏伟, 等.盐酸伊立替康的药理特性及临床应用 [J]. 河北职工医学院学报, 2007, 24(1): 61-62+64. |
| [11] | 安云婷, 郑子雯. 伊立替康联合铂类治疗复发性卵巢癌临床研究 [J]. 实用肿瘤杂志, 2012, 27(01): 88-90. |
| [12] | 雷妍玮, 宫深谋. 伊立替康联合希罗达一线治疗晚期大肠癌近期疗效观察 [J]. 中国实用医药, 2012, 7(03): 171-172. |
| [13] | Ambudkar S V, Kimchi-Sarfaty C, Sauna Z E, et al. P-glycoprotein: from Genomics to Mechanism [J]. Oncogene, 2003, 22(47): 7468-7485. |
| [14] | 韩继永, 贾佳. HPLC法测定盐酸伊立替康注射液的含量及有关物质 [J]. 药物分析杂志, 2013, 33(04): 648-652. |
| [15] | 杜昌文, 周健民. 金属有机框架（MOF）材料及其在新型缓控释肥料中的应用 [J]. 华中农业大学学报(自然科学版), 2022, 41(02): 20-29. |
| [16] | Serre C, Millange F, Surblé S, et al. A route to the synthesis of trivalent transition-metal porous carboxylates with trimeric secondary building units [J]. Angewandte Chemie International Edition, 2004, 43(46): 6285-6289. |
| [17] | Bellusci M, Guglielmi P, Masi A, et al. Magnetic metal–organic framework composite by fast and facile mechanochemical process [J]. Inorganic chemistry, 2018, 57(4): 1806-1814. |
| [18] | Nehra M, Dilbaghi N, Singhal N K, et al. Metal organic frameworks MIL-100 (Fe) as an efficient adsorptive material for phosphate management [J]. Environmental research, 2019, 169: 229-236. |
| [19] | Conde-González J E, Lorenzo-Luis P, Salvadó V, et al. A new cotton functionalized with iron(III) trimer-like metal framework as an effective strategy for the adsorption of triarylmethane dye: An insight into the dye adsorption processes [J]. Heliyon, 2021, 7(12): e08524. |
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