World Journal of Clinical Medicine is an international, peer-reviewed open access journal dedicated to advancing research the field of clinical medicine. The journal provides a rapid publication process to ensure wide dissemination of high-quality articles to scientists, professionals, and interested individuals worldwide. Our goal is to serve as an efficient, reliable, and trusted platform for scholars and readers, publishing cutting-edge research in the field.
Abstract: To systematically synthesize the literature on the Singing Voice Handicap Index-10 (SVHI-10), a concise patient-reported outcome measure designed specifically for singers, this study followed PRISMA 2020 guidelines. Databases including PubMed, Scopus, Web of Science, and Embase were searched from inception to March 2026. Peer-reviewed studies reporting development, validation, reliability, validity, normative values, minimal clinically important difference (MCID), or clinical applications were included. Quality was assessed using the COSMIN checklist. Of 152 records screened, 22 studies were included. The original SVHI and abbreviated SVHI-10 showed excellent psychometrics (Cronbach’s α ≥ 0.94). Validated adaptations exist in at least eight languages, including Mandarin, Italian, Turkish, Kannada, Persian, and Hindi. Normative data yielded pooled means of 8.38–9.13 in healthy singers, with scores ≥20 considered abnormal. The MCID was established as 9.5–10 points. The SVHI-10 demonstrates superior singer-specific sensitivity and responsiveness compared with the VHI-10. The SVHI-10 is a reliable, valid, and clinically actionable PROM. Its Mandarin version (MSVHI-10) is particularly relevant for Chinese populations. Future research should focus on longitudinal responsiveness and non-Western singing styles.Abstract: To systematically synthesize the literature on the Singing Voice Handicap Index-10 (SVHI-10), a concise patient-reported outcome measure designed specifically for singers, this study followed PRISMA 2020 guidelines. Databases including PubMed, Scopus, Web of Science, and Embase were searched from inception to March 2026. Peer-reviewed studies repor...Learn More
Abstract: Bainbridge-Ropers syndrome (BRPS) is a rare autosomal dominant multisystem developmental disorder caused by loss-of-function variants in the additional sex combs-like 3 (ASXL3) gene. With few cases reported worldwide, its clinical manifestations during infancy lack specificity, rendering it highly susceptible to missed diagnosis and misdiagnosis.This paper reports the clinical diagnosis and treatment process of a child with BRPS. Through integration of genetic testing results, pathological characteristics analysis, and a literature review, this article discusses explore the clinical features, diagnostic key points, and management strategies of this disease. The patient is a 5-month-and-8-day-old male infant, admitted with the chief complaint of "feeding difficulty for 5 months, aggravated in the past 3 days." He presented with pauses during feeding and frequent choking since the neonatal period, accompanied by chronically inadequate milk intake. Physical examination revealed slow weight gain and developmental delay compared with age-matched peers. After completing relevant examinations, infectious diseases, anatomical gastrointestinal malformations, cow’s milk protein allergy and common metabolic disorders were excluded. Whole-exome high-throughput sequencing identified a heterozygous variant c.3380_3381insT (p.R1128Pfs*22) in the additional sex combs-like 3 (ASXL3) gene. Combined with the clinical phenotype and imaging manifestations, the findings met the diagnostic criteria for BRPS. Currently, the infant is receiving nasogastric tube feeding at home, but vomiting and reflux remain significant during feeding, with poor responsiveness. By analyzing the clinical characteristics and genetic test results of this case along with a systematic literature review, this study aims to enhance clinicians' understanding of the disease and improve early diagnostic ability, facilitate timely genetic testing in children suspected of developmental delay with intractable feeding difficulties, and support early recognition of BRPS as well as long-term standardized symptomatic intervention.Abstract: Bainbridge-Ropers syndrome (BRPS) is a rare autosomal dominant multisystem developmental disorder caused by loss-of-function variants in the additional sex combs-like 3 (ASXL3) gene. With few cases reported worldwide, its clinical manifestations during infancy lack specificity, rendering it highly susceptible to missed diagnosis and misdiagnosis.Th...Learn More
