Medical Research Frontiers is an international, peer-reviewed open access journal dedicated to advancing research the field of medical research. The journal provides a rapid publication process to ensure wide dissemination of high-quality articles to scientists, professionals, and interested individuals worldwide. Our goal is to serve as an efficient, reliable, and trusted platform for scholars and readers, publishing cutting-edge research in the field.
Abstract: RNA binding motif (RBM) proteins are a class of RNA binding proteins, It's involved in a lot of functions in cells, they are involved in various physiological and pathological processes at multiple levels such as cell signal transduction, gene expression and body metabolism. They have been widely concerned by researchers due to their wide and stable expression in organisms. In recent years, many researchers have found that the RBM family is involved in the splicing of pre-mRNA, and plays an important role in maintaining the conformation of the catalytic core of the splicosome, and also acts as a bridge between the catalytic core and other essential protein components of the splicosome. Because of its wide range of gene expression regulation, the RBM protein family is associated with autoimmune diseases, inflammation and a variety of cancers, Many studies have shown that RBM protein family may be a therapeutic target for various diseases. This article reviews the role and mechanism of RBM protein family, especially in tumors, and provides reference for the treatment and prognosis of related diseases.Abstract: RNA binding motif (RBM) proteins are a class of RNA binding proteins, It's involved in a lot of functions in cells, they are involved in various physiological and pathological processes at multiple levels such as cell signal transduction, gene expression and body metabolism. They have been widely concerned by researchers due to their wide and stabl...Learn More
Abstract: Purpose: Arthroscopic Posterior cruciate ligament (PCL) reconstruction is widely used for patients with PCL injury. However, results of PCL reconstruction always tend to be less satisfied than anterior cruciate ligament (ACL) reconstruction when it comes to laxity and stability control. It is crucial for successful PCL reconstruction with arthroscopic tibial tunnel techniques to place tibial tunnel in an accurate position. Current surgical recommendations for tibial tunnel placement only emphasize that tibial tunnel should be placed in the anatomical tibial PCL insertion site, but no specific position suggest is mentioned. The purpose of this review was to identify the optimal placement of the tibial tunnel in PCL reconstruction. Methods: A systematic review was conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. In this systematic review of literature, articles about tibial tunnel for PCL reconstruction was searched via PubMed and Cochrane Library databases from January 2000 to December 2022. All clinical trials, biomechanical studies, anatomical studies and radiological studies were extracted and analyzed. Clinical studies only comparing different tibial tunnel placement techniques were included, and other studies mentioning specific tibial tunnel placement were included. Results: There were 2 comparative clinical trials for the entry of tibial tunnel in PCL reconstruction and 0 for the exit. 16 anatomical studies have described the anatomical PCL tibial insertion sites, and 10 biomechanical studies have compared different tibial tunnel placements. Anterolateral entry of the tibial tunnel shows a better outcome in terms of the objective and biomechanical results, while there is no significant difference in clinical results as judged by Lysholm and International Knee Documentation Committee (IKDC) scores. Several anatomical and radiological landmarks were used to analyze the tibial insertion sites of the native PCL. Although some of biomechanical studies have compared the tibial tunnel exit between anterolateral bundle (ALB) center and posteromedial bundle (PMB) center, there was no consensus on the exit position of the tibial tunnel. Conclusions: With a detailed cartography of the PCL fovea and reliable anatomical landmarks, more randomized controlled trials are needed for the entry placement of the tibial tunnel to confirm the preference of anterolateral tibial tunnel, while an established map of the PCL fovea and biomechanical studies comparing different pin centers are required for the exit placement of the tibial tunnel for PCL reconstruction. Both the entry and exit placement have the absence of high-quality studies with long-term follow-up.Abstract: Purpose: Arthroscopic Posterior cruciate ligament (PCL) reconstruction is widely used for patients with PCL injury. However, results of PCL reconstruction always tend to be less satisfied than anterior cruciate ligament (ACL) reconstruction when it comes to laxity and stability control. It is crucial for successful PCL reconstruction with arthrosco...Learn More
