RNA-binding Motif Proteins Influence Tumour Progression by Regulating Gene Expression
Department of Otorhinolaryngology, Head and Neck Surgery, No. 940 Hospital of the Joint Logistics and Security Force of the Chinese People's Liberation Army, Lanzhou 730000, China
| Abstract: | RNA binding motif (RBM) proteins are a class of RNA binding proteins, It's involved in a lot of functions in cells, they are involved in various physiological and pathological processes at multiple levels such as cell signal transduction, gene expression and body metabolism. They have been widely concerned by researchers due to their wide and stable expression in organisms. In recent years, many researchers have found that the RBM family is involved in the splicing of pre-mRNA, and plays an important role in maintaining the conformation of the catalytic core of the splicosome, and also acts as a bridge between the catalytic core and other essential protein components of the splicosome. Because of its wide range of gene expression regulation, the RBM protein family is associated with autoimmune diseases, inflammation and a variety of cancers, Many studies have shown that RBM protein family may be a therapeutic target for various diseases. This article reviews the role and mechanism of RBM protein family, especially in tumors, and provides reference for the treatment and prognosis of related diseases. |
| Keywords: | RBM Protein Family; Cancer; Research Mechanism |
| DOI: | 10.57237/j.mrf.2025.01.001 |
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Received: 25 November 2024
Accepted: 18 January 2025
Published Online: 13 March 2025
Funding
| 1. | 省级青年科技基金 (批准No. 20JR10RA011) |
References
| [1] | 管小雪, 张小玲. RBM家族在肝癌中作用及其机制的研究进展 [J]. 华夏医学, 2023, 36(02): 174-179. |
| [2] | Ciavarella J, Perea W, Greenbaum NL. Topology of the U12-U6atac snRNA Complex of the Minor Spliceosome and Binding by NTC-Related Protein RBM22. ACS Omega. 2020 Sep 4; 5(37): 23549-23558. https://doi.org/10.1021/acsomega.0c01674. |
| [3] | Rasche N, Dybkov O, Schmitzová J, Akyildiz B, Fabrizio P, Lührmann R. Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre. EMBO J. 2012 Mar 21; 31(6): 1591-604. https://doi.org/10.1038/emboj.2011.502. |
| [4] | Zhang X, Yan C, Hang J, Finci LI, Lei J, Shi Y. An Atomic Structure of the Human Spliceosome. Cell. 2017 May 18; 169(5): 918-929. e14. https://doi.org/10.1016/j.cell.2017.04.033. |
| [5] | Du X, Qin W, Yang C, Dai L, San M, Xia Y, Zhou S, Wang M, Wu S, Zhang S, Zhou H, Li F, He F, Tang J, Chen JY, Zhou Y, Xiao R. RBM22 regulates RNA polymerase II 5' pausing, elongation rate, and termination by coordinating 7SK-P-TEFb complex and SPT5. Genome Biol. 2024 Apr 19; 25(1): 102. https://doi.org/10.1186/s13059-024-03242-6 |
| [6] | Bushweller J. H. (2019). Targeting transcription factors in cancer - from undruggable to reality. Nature reviews. Cancer, 19(11), 611–624. https://doi.org/10.1038/s41568-019-0196-7 |
| [7] | Lee, S. C., & Abdel-Wahab, O. (2016). Therapeutic targeting of splicing in cancer. Nature medicine, 22(9), 976–986. https://doi.org/10.1038/nm.4165 |
| [8] | Janowicz A, Michalak M, Krebs J. Stress induced subcellular distribution of ALG-2, RBM22 and hSlu7. Biochim Biophys Acta. 2011 May; 1813(5): 1045-9. https://doi.org/10.1016/j.bbamcr.2010.11.010 |
| [9] | Krebs J. The influence of calcium signaling on the regulation of alternative splicing. Biochim Biophys Acta. 2009 Jun; 1793(6): 979-84. https://doi.org/10.1016/j.bbamcr.2008.12.006 |
| [10] | Montaville P, Dai Y, Cheung CY, Giller K, Becker S, Michalak M, Webb SE, Miller AL, Krebs J. Nuclear translocation of the calcium-binding protein ALG-2 induced by the RNA-binding protein RBM22. Biochim Biophys Acta. 2006 Nov; 1763(11): 1335-43. https://doi.org/10.1016/j.bbamcr.2006.09.003 |
| [11] | He F, Wang CT, Gou LT. RNA-binding motif protein RBM22 is required for normal development of zebrafish embryos. Genet Mol Res. 2009 Dec 8; 8(4): 1466-73. https://doi.org/10.4238/vol8-4gmr683 |
| [12] | Boultwood J, Pellagatti A, Cattan H, Lawrie CH, Giagounidis A, Malcovati L, Della Porta MG, Jädersten M, Killick S, Fidler C, Cazzola M, Hellström-Lindberg E, Wainscoat JS. Gene expression profiling of CD34+ cells in patients with the 5q- syndrome. Br J Haematol. 2007 Nov; 139(4): 578-89. https://doi.org/10.1111/j.1365-2141.2007.06833.x |
| [13] | 张赟恺. 剪接体蛋白RBM25和RBM22在炎症反应和自身免疫中的作用及表观机制研究 [D]. 中国人民解放军海军军医大学, 2024. https://doi.org/10.26998/d.cnki.gjuyu.2023.000004 |
| [14] | Douet-Guilbert N, Soubise B, Bernard DG, Troadec MB. Cytogenetic and Genetic Abnormalities with Diagnostic Value in Myelodysplastic Syndromes (MDS): Focus on the Pre-Messenger RNA Splicing Process. Diagnostics (Basel). 2022 Jul 7; 12(7): 1658. https://doi.org/10.3390/diagnostics12071658 |
| [15] | 刘祎, 张小玲. RNA结合蛋白RBM10及其涉及的主要疾患 [J]. 华夏医学, 2022, 35(03): 135-139. https://doi.org/10.19296/j.cnki.1008-2409.2022-03-032 |
| [16] | 谢亚斐. RBM25调控Bcl2/Bax凋亡信号通路在缺血性心力衰竭中的作用及机制研究 [D]. 兰州大学, 2023. https://doi.org/10.27204/d.cnki.glzhu.2023.003569 |
| [17] | 庞锡泉. Rbm38磷酸化影响代谢的分子机制研究 [D]. 华中农业大学, 2023. https://doi.org/10.27158/d.cnki.ghznu.2022.001163 |
| [18] | Fagerberg L, Hallström BM, Oksvold P, Kampf C, Djureinovic D, Odeberg J, Habuka M, Tahmasebpoor S, Danielsson A, Edlund K, Asplund A, Sjöstedt E, Lundberg E, Szigyarto CA, Skogs M, Takanen JO, Berling H, Tegel H, Mulder J, Nilsson P, Schwenk JM, Lindskog C, Danielsson F, Mardinoglu A, Sivertsson A, von Feilitzen K, Forsberg M, Zwahlen M, Olsson I, Navani S, Huss M, Nielsen J, Ponten F, Uhlén M. Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics. Mol Cell Proteomics. 2014 Feb; 13(2): 397-406. https://doi.org/10.1074/mcp.M113.035600 |
| [19] | Kittler R, Putz G, Pelletier L, Poser I, Heninger AK, Drechsel D, Fischer S, Konstantinova I, Habermann B, Grabner H, Yaspo ML, Himmelbauer H, Korn B, Neugebauer K, Pisabarro MT, Buchholz F. An endoribonuclease-prepared siRNA screen in human cells identifies genes essential for cell division. Nature. 2004 Dec 23; 432(7020): 1036-40. https://doi.org/10.1038/nature03159 |
| [20] | Ganaie SS, Chen AY, Huang C, Xu P, Kleiboeker S, Du A, Qiu J. RNA Binding Protein RBM38 Regulates Expression of the 11-Kilodalton Protein of Parvovirus B19, Which Facilitates Viral DNA Replication. J Virol. 2018 Mar 28; 92(8): e02050-17. https://doi.org/10.1128/JVI.02050-17 |
| [21] | 蒋峰, 孙晓虹, 高艺文, 王婷婷, 秦海洸. 斑蝥酸钠维生素B6注射液联合不同化疗药物对晚期肝癌患者RBM38、SPATS2及预后的影响 [J]. 中西医结合肝病杂志, 2023, 33(03): 237-241. |
| [22] | Mossmann D, Müller C, Park S, Ryback B, Colombi M, Ritter N, Weißenberger D, Dazert E, Coto-Llerena M, Nuciforo S, Blukacz L, Ercan C, Jimenez V, Piscuoglio S, Bosch F, Terracciano LM, Sauer U, Heim MH, Hall MN. Arginine reprograms metabolism in liver cancer via RBM39. Cell. 2023 Nov 9; 186(23): 5068-5083.e23. https://doi.org/10.1016/j.cell.2023.09.011 |
| [23] | 王张立, 吴晓旭, 崔阳等. 胶质母细胞瘤组织RBM8A表达与病人预后及替莫唑胺化疗敏感性的关系 [J]. 中国临床神经外科杂志, 2022, 27(06): 468-470+473. https://doi.org/10.13798/j.issn.1009-153X.2022.06.011 |
| [24] | 李德成. RBM19在人脑胶质瘤放化疗抵抗中的作用及机制研究 [D]. 中南大学, 2022. https://doi.org/10.27661/d.cnki.gzhnu.2022.003231 |
| [25] | 黄意超. RBM8A在乳腺癌组织中的表达及调控乳腺癌侵袭、转移机制的研究 [D]. 南华大学, 2022. https://doi.org/10.27234/d.cnki.gnhuu.2022.000185 |
| [26] | 王冲. RBM45缺失通过促进IFNB1转录抑制乳腺癌的进展[D]. 大连医科大学, 2024. |
| [27] | 谭冬梅, 张静静, 师一民等. RBM8A基因对子宫内膜癌HEC-1A细胞增殖、迁移和凋亡的作用及其机制 [J]. 肿瘤防治研究, 2023, 50(01): 27-32. |
| [28] | 唐茗. m6A甲基化甲基转移酶RBM15在宫颈癌中的表达及临床意义 [D]. 皖南医学院, 2023. |
| [29] | 薄祥坤,朱日祥,陈晋,等.18F-FDG PET/CT联合血清RNA结合基序蛋白38检测对结直肠癌术后复发/转移的诊断具有预测价值[J/OL].分子影像学杂志, 1-5 [2025-01-15]. http://kns.cnki.net/kcms/detail/44.1630.r.20250110.1719.008 |
| [30] | Jiménez-Vacas JM, Montero-Hidalgo AJ, Gómez-Gómez E, Sáez-Martínez P, Fuentes-Fayos AC, Closa A, González-Serrano T, Martínez-López A, Sánchez-Sánchez R, López-Casas PP, Sarmento-Cabral A, Olmos D, Eyras E, Castaño JP, Gahete MD, Luque RM. Tumor suppressor role of RBM22 in prostate cancer acting as a dual-factor regulating alternative splicing and transcription of key oncogenic genes. Transl Res. 2023 Mar; 253: 68-79. https://doi.org/10.1016/j.trsl.2022.08.016 |
| [31] | 钟传帆. M6A修饰介导circRBM33-FMR1复合物形成增强线粒体呼吸促进前列腺癌进展的机制研究 [D]. 南方医科大学, 2023. https://doi.org/10.27003/d.cnki.gojyu.2023.000090 |
| [32] | 李姣. 口腔鳞状细胞癌患者m6A相关生物标志物的鉴定 [J]. 长治医学院学报, 2023, 37(04): 241-246. |
| [33] | 向水波, 肖胜军. RBM10在肿瘤细胞凋亡途径中的研究进展 [J]. 临床与实验病理学杂志, 2024, 40(08): 857-861. https://doi.org/10.13315/j.cnki.cjcep.2024.08.015 |
| [34] | 王小林. 敲低RBM17对下咽癌的顺铂敏感性、迁移、侵袭和EMT的影响 [D]. 蚌埠医学院, 2023. https://doi.org/10.26925/d.cnki.gbbyc.2023.000257 |
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