Clinical Medicine Frontiers is an international, peer-reviewed open access journal dedicated to advancing research the field of clinical medicine. The journal provides a rapid publication process to ensure wide dissemination of high-quality articles to scientists, professionals, and interested individuals worldwide. Our goal is to serve as an efficient, reliable, and trusted platform for scholars and readers, publishing cutting-edge research in the field.
Abstract: Aim: The mechanism of lycium barbarum treatment liver cancer was explored based on network pharmacology. Methods: The active ingredients, action targets of Lycium barbarum and disease targets of liver cancer were searched in public database platforms TCMSP, GeneCards, DisGeNET, OMIM and TTD, and the potential target of lycium barbarum in the treatment of liver cancer was obtained by intersection of drug component target and disease target. The protein interaction network (PPI) of lycium barbarum in treating liver cancer was obtained through STRING database, and the core target was identified by Cytoscape3.9.1 software analysis. The signaling pathway of lycium barbarum on hepatocarcinoma were screened by gene ontology (GO) enrichment analysis and Genomic Encyclopedia (KEGG) pathway enrichment analysis. Results: 45 active ingredients and 430 targets of Lycium barbarum, and 6489 targets related to liver cancer were selected. There were 272 common targets of drug-disease intersection. The analysis results showed that the active components of Lycium berry mainly included δ-carotene, lano-8-enol, lano-8-ene-3beta-alcohol, 14b-pregnane, β-sitosterol, and carotenin. The core targets of lycium barbarum in the treatment of liver cancer include AKT1, TNF, EGFR, ESR1, SRC, PPARG and HSP90AA1. GO enrichment is mainly involved in biological processes such as protein phosphorylation, response to exogenous stimuli, and negative regulation of apoptosis. KEGG is mainly involved in metabolic pathway, cancer pathway, PI3K-Akt signaling pathway. Conclusions: The results of this study show that Lycium barbarum may play an important role for treatment liver cancer in protein phosphorylation, exogenous stimulus response and negative regulation of apoptosis through key targets such as AKT1, TNF, EGFR, ESR1, SRC, PPARG and HSP90AA1 in "metabolic pathway", "tumor pathway" and "PI3K-Akt signaling pathway".Abstract: Aim: The mechanism of lycium barbarum treatment liver cancer was explored based on network pharmacology. Methods: The active ingredients, action targets of Lycium barbarum and disease targets of liver cancer were searched in public database platforms TCMSP, GeneCards, DisGeNET, OMIM and TTD, and the potential target of lycium barbarum in the treatm...Learn More
Abstract: Thyroid nodules, breast hyperplasia, and uterine fibroids are common endocrine and reproductive system diseases, and their incidence is increasing annually, severely affecting women's health and quality of life. Although numerous studies have explored their pathogenesis, many mysteries remain unsolved. According to traditional Chinese medicine, these three diseases are all emotional disorders related to stagnation of the liver qi. Western medicine also recognizes certain commonalities in the etiology of these three diseases, especially in the interactions among hormone levels, genetic factors, and environmental influences. These diseases not only are independent pathological states but also may exhibit interactions and potential common mechanisms in certain patients. Understanding the etiology of these diseases is crucial for their management and clinical intervention. Genetic factors, environmental factors, and changes in hormone levels are considered the main influencing factors of these diseases, but the specific mechanisms of action still require in-depth research. A deeper understanding of the causes and interrelationships of thyroid nodules, breast hyperplasia, and uterine fibroids not only aids in promoting the development of personalized medicine but also provides important directional guidance for future research. The integrated perspective of traditional Chinese and Western medicine allows us to gain a more comprehensive understanding of these three diseases, thereby optimizing clinical management strategies and ultimately enhancing the quality of life of patients. This study aims to comprehensively analyze and explore the etiology and interrelationships of thyroid nodules, breast hyperplasia, and uterine fibroids from a combined traditional Chinese and Western medicine perspective, reveal the multiple factors that affect the development of these diseases, and discuss future research directions and their potential impact on clinical practice.Abstract: Thyroid nodules, breast hyperplasia, and uterine fibroids are common endocrine and reproductive system diseases, and their incidence is increasing annually, severely affecting women's health and quality of life. Although numerous studies have explored their pathogenesis, many mysteries remain unsolved. According to traditional Chinese medicine, the...Learn More
