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Abstract: Objective: To evaluate the clinical efficacy of "Jingjin Dongci" combined with "Jian Yu Zhi Tong Decoction" in the treatment of wind-cold-damp-type periarthritis of the shoulder. Methods: A total of 90 patients with wind-cold damp arthralgia-type periarthritis of the shoulder who met the inclusion criteria from the Rehabilitation Medicine Department outpatient clinic of Changle People's Hospital from March 2024 to October 2024 were included. They were randomly divided into a treatment group, an observation group 1, and an observation group 2 at a 1:1:1 ratio. The treatment group received "Jingjin Dongci" combined with "Jian Yu Zhi Tong Decoction" for acupuncture and medication treatment. Observation group 1 received electroacupuncture treatment. Observation group 2 received loxoprofen sodium treatment. After 2 weeks and 4 weeks of treatment, the differences in pain visual analog scale (VAS) scores, Constant‒Murley shoulder function (CMS) scores, traditional Chinese medicine symptom (TCMS) scores, and clinical efficacy rates among the three groups were compared, and safety evaluations were conducted. Results: Within-group comparisons revealed that after treatment, the VAS scores, CMS scores, TCMS scores, and clinical efficacy rates of all three groups were significantly better than those before treatment (P > 0.05). Between-group comparisons revealed that after 2 weeks of treatment, the VAS scores, CMS scores, TCMS scores, and clinical efficacy rates in the treatment group were significantly better than those in observation group 1 and observation group 2 (P < 0.05). After 4 weeks of treatment, the VAS scores, CMS scores, TCMS scores, and clinical efficacy rates in the treatment group were significantly better than those in observation group 1 and observation group 2, with highly significant differences (P < 0.01). Conclusion: "Jingjin Dongci" combined with "Jian Yu Zhi Tong Decoction" is effective in treating wind‒cold-damp-type periarthritis of the shoulder, can relieve shoulder pain, promote the recovery of shoulder joint function, and has good safety, indicating its clinical application value.Abstract: Objective: To evaluate the clinical efficacy of "Jingjin Dongci" combined with "Jian Yu Zhi Tong Decoction" in the treatment of wind-cold-damp-type periarthritis of the shoulder. Methods: A total of 90 patients with wind-cold damp arthralgia-type periarthritis of the shoulder who met the inclusion criteria from the Rehabilitation Medicine Departmen...Learn More
Abstract: Background: Both lung cancer and liver cancer are malignant tumors worldwide. In clinical practice, co-morbidities of lung cancer and liver cancer are not uncommon. As lung cancer and liver cancer share some common pathways in their pathogenesis, the research on co-treatment drugs for the two cancers is needed to explore potential therapeutic agents. Case information: Alkaloids of Sophora flavescens contains active ingredients and exhibits antitumor activities, but its synergistic mechanism has not been elucidated. In the present study, network pharmacology was used as a powerful tool to investigate the potential mechanism of Alkaloids of Sophora flavescens in the co-treatment of lung cancer and liver cancer. Discussion: In Alkaloids of Sophora flavescens, a total of thirteen alkaloids could co-treat lung and liver cancers by acting on 223 key targets, in which five core targets were obtained in both lung cancer and liver cancer based on the network pharmacology approach. There were six alkaloids which had a greater effect on the two cancers. The biological processes involved 10 biological processes, 10 cellular components and 10 molecular functions. Conclusion: The present study revealed the potential mechanism and provided a systematical theoretical basis for clinical application of Alkaloids of Sophora flavescens in the co-treatment of lung cancer and liver cancer.Abstract: Background: Both lung cancer and liver cancer are malignant tumors worldwide. In clinical practice, co-morbidities of lung cancer and liver cancer are not uncommon. As lung cancer and liver cancer share some common pathways in their pathogenesis, the research on co-treatment drugs for the two cancers is needed to explore potential therapeutic agent...Learn More
