The Clinical Effect of Jindan Paishi Decoction on Ureteral Calculus with Damp-Heat Syndrome
1. Department of Radiology, Liver Oncology, Qingdao Sixth People’s Hospital, Qingdao 266023, China
2. Department of Pharmacy, TCM Medicine, Pingyi County People’s Hospital, Pingyi 273300, China
3. Institute of Integrate Medicine, Qingdao Hiser Hospital Affiliated to Qingdao University, Qingdao 266021, China
| Abstract: | Objective: This study aims to explore the clinical effect of Jindan Paishi (JDPS) decoction in treating patients of ureteral calculus with damp-heat syndrome. Methods: Total of 62 patients of ureteral calculus with damp-heat syndrome hospitalized in Pingyi County People’s Hospital from Jan 2021 to Dec 2022 were randomly divided into the control group (n=31) orally given Shenshitong (SHST) granules and the treatment group (n=31) orally given SHST granules + JDPS decoction for 30 days continuously. The pain degrees of patients were evaluated according to World Health Organization Pain Grade Standard. The traditional Chinese medicine (TCM) syndromes, micturition frequency and urine volume were recorded according to the principles of Clinical Research Criteria of New Chinese Medicine. The number of WBC and RBC in urine, the number and classification of WBC in blood, the serum levels of creatinine (Cr) and urea nitrogen (BUN) were determined by biochemical assay. The size and number of ureteral calculus were detected by imaging examination, and at last the total effective rate of the two drugs was evaluated comprehensively. Results: (1) Comparison between before and after treatment in the two groups: After treatment, all the pain degree and pain time, the tongue coating color and pulse conditions, the size and number of ureteral calculus, the urine volume and frequency of patients were significantly improve than those before treatment respectively; the numbers of WBC and RBC in urine were significantly decreased than those before treatment; the serum levels of Cr and BUN were significantly decreased than those before treatment; the number of WBC and neutrophils in blood were significantly reduced than those before treatment, P<0.01. (2) Comparison between control and treatment groups after treatment: The pain degree and time of patients in treatment group were significantly decreased than those in control group, P<0.05; the number of WBC in urine, the serum levels of Cr and BUN, and the number of WBC and neutrophils in blood in treatment group were significantly lower than those in control group, P<0.01. (3) The total effective rate of patients in treatment group (90.32%) was significantly higher than that in control group (80.64%), P<0.01. Conclusions: JDPS decoction might improve clinical symptoms and renal function of patients of ureteral calculus with damp-heat syndrome. |
| Keywords: | Jindan Paishi Decoction; Ureteral Calculus; Damp-Heat Syndrome; Clinical Effect |
| DOI: | 10.57237/j.wjcm.2024.04.001 |
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收稿日期: 2024-09-10
接受日期: 2024-11-19
在线出版日期: 2024-12-05
基金
| 1. | National Natural Science Foundation of China (Grant No. GA2024ZZ05) |
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