间苯二酚的工艺开发现状及其在中国医药领域的研究进展
1. 内蒙古大唐药业股份有限公司, 内蒙古盛唐国际蒙医药研究院, 内蒙古自治区蒙药新药研发企业重点实验室, 内蒙古呼和浩特 010010
2. 内蒙古医科大学药学院, 基于化学生物学的候选药物设计与筛选重点实验室, 内蒙古呼和浩特 010110
| 摘 要： | 间苯二酚作为一种精细化工原料，广泛应用于医药、橡胶、塑料、染料等领域。而在中国药品制剂领域，间苯二酚目前仅作为原料药应用于复方外用制剂，在其他方面的应用较少。目前，合成间苯二酚的主要工业化方法为苯磺化碱溶法和间二异丙苯氧化法，二者具有产率高、副产物少等优势，但同时也具有反应条件苛刻、化工污染等缺点。因此，如何设计出更简单、更绿色、更环保的合成方法，来弥补苯磺化碱溶法和间二异丙苯氧化法的缺陷已经成为当前研究热点。随着对间苯二酚合成方法的研究，目前已经发现了间苯二胺水解法、间二氯苯水解法、硫酸铜水解法、间二苯甲酸氧化法、芳化法、苯酚羟基化法等各具不同优势的能够用于间苯二酚工业合成的方法。本文概括了现有间苯二酚的工艺合成方法，并对间苯二酚在中国医药领域的研究进展总结并展望。 |
| 关 键 词： | 间苯二酚; 研究进展; 医药应用; 合成工艺 |
| DOI： | 10.57237/j.se.2024.03.005 |
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收稿日期: 2024-05-22
接受日期: 2024-06-17
在线出版日期: 2024-06-18
The Process Development Current Status and Research Progress in the Chinese Medicine Field of Resorcinol
1. Inner Mongolia Datang Pharmaceutical Co., Ltd, Inner Mongolia Shengtang International Research Institute of Mongolian Medicine, Inner Mongolia Autonomous Region Key Laboratory for Research and Development of New Mongolian Medicines, Hohhot 010010, China
2. Key Laboratory for Candidate Drug Design and Screening Based on Chemical Biology, School of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China
| Abstract: | As the fine chemical raw material, resorcinol is widely used in pharmaceuticals, rubber, plastics, dyestuffs and other fields. In Chinese medicine field, resorcinol is currently only used as an API in compounded topical preparations, with fewer applications in other areas. At present, the main industrial methods for synthesizing resorcinol are benzene sulfonation alkaline dissolution method and m-diisopropylbenzene oxidation method, which have advantages such as high yield and few by-products. However, it also has the disadvantages of harsh reaction conditions and chemical pollution. Therefore, how to design a simpler, greener and more environmentally friendly synthetic method to make up for the shortcomings has become a hot research topic at present. With the study of synthetic methods for resorcinol, resorcinolamine hydrolysis, m-dichlorobenzene hydrolysis, copper sulfate hydrolysis, m-dibenzoic acid oxidation, aromatization, phenol hydroxylation, etc. could also be used for the industrial synthesis of resorcinol. This paper outlines the current process synthesis methods of resorcinol, and summarizes and prospects the research progress of in our country. |
| Keywords: | Resorcinol; Research Progress; Medicine Applications; Synthesis Process |
基金
| 1. | 呼和浩特市重大科技专项 (2022-社-重-3-1) |
| 2. | 内蒙古医科大学学科建设项目 (YKD2024XK006) |
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