Green Alternatives in Personal Hygiene: Evaluating Bioalcohols in Wipes, Hand Sanitizers, and Sprays
Zhujiang Hospital of Southern Medical University, Guangzhou 510288, China
| Abstract: | The widespread use of petrochemical-derived alcohols in personal care and disinfectant products has raised growing concerns over environmental sustainability and human health safety. As the global demand for eco-friendly healthcare solutions intensifies, bioalcohols—notably bioethanol and biobutanol produced from renewable biomass—have emerged as compelling alternatives. This review systematically evaluates the integration of bioalcohols into personal care formulations, with a particular focus on wipes, hand sanitizers, and spray-based disinfectants. Drawing upon recent advances in green chemistry, toxicology, and industrial biotechnology, we assess the performance, safety profile, and environmental impact of bioalcohols relative to their fossil-based counterparts. While challenges persist—such as supply chain scalability, cost competitiveness, and formulation stability—our analysis reveals that bioalcohol adoption can significantly reduce carbon emissions and volatile organic compound (VOC) release in consumer products. The study concludes with strategic recommendations encompassing regulatory incentives, standardization frameworks, public education, and technological innovation, charting a pathway toward the mainstream deployment of bioalcohols in sustainable healthcare and hygiene applications. |
| Keywords: | Bioalcohols; Personal Care Products; Green Disinfectants; Sustainable Nursing; Wipes; Hand Sanitizers; Sprays |
| DOI: | 10.57237/j.nhres.2025.02.002 |
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收稿日期: 2025-04-15
接受日期: 2025-06-24
在线出版日期: 2025-07-04
参考文献
| [1] | Ziylan-Yavas A, Santos D, Flores E M M, et al. Pharmaceuticals and personal care products (PPCPs): Environmental and public health risks [J]. Environmental Progress & Sustainable Energy, 2022, 41(4): e13821. https://doi.org/10.1002/EP.13821 |
| [2] | Tasar R, Wiegand C, Elsner P. How irritant are n-propanol and isopropanol? – A systematic review [J]. Contact Dermatitis, 2021, 84(1): 1-14. https://doi.org/10.1111/COD.13722 |
| [3] | Sharif N, Munir N, Hasnain M, et al. Environmental Impacts of Ethanol Production System [J]. Sustainable Ethanol and Climate Change: Sustainability Assessment for Ethanol Distilleries, 2021: 205-223. https://doi.org/10.1007/978-3-030-59280-6_10 |
| [4] | Rutz D, Janssen R. Biofuel technology handbook [M]. Munchen, Germany: WIP Renewable energies, 2008. |
| [5] | Manochio C, Andrade B R, Rodriguez R P, et al. Ethanol from biomass: A comparative overview [J]. Renewable and Sustainable Energy Reviews, 2017, 80: 743-755. https://doi.org/10.1016/J.RSER.2017.05.063 |
| [6] | Xie S, Song W, Yi C, et al. Salting-out extraction systems of ethanol and water induced by high-solubility inorganic electrolytes [J]. Journal of Industrial and Engineering Chemistry, 2017, 56: 145-150. https://doi.org/10.1016/j.jiec.2017.07.006 |
| [7] | Xie S, Zhang Y, Zhou Y, et al. Salting-out of bio-based 2,3-butanediol from aqueous solutions [J]. Journal of Chemical Technology and Biotechnology, 2017, 92(1): 122-132. https://doi.org/10.1002/jctb.4999 |
| [8] | Xie S, Qiu X, Ji W, et al. Salting-out of 1,3-propanediol from aqueous solutions by inorganic electrolytes [J]. Journal of Chemical Technology & Biotechnology, 2016, 91(11): 2793-2801. https://doi.org/10.1002/JCTB.4886 |
| [9] | Demirbas A. Progress and recent trends in biofuels [J]. Progress in Energy and Combustion Science, 2007, 33(1): 1-18. https://doi.org/10.1016/J.PECS.2006.06.001 |
| [10] | Fu C, Li Z, Zhang Y, et al. Assessment of extraction options for a next‐generation biofuel: Recovery of bio‐isobutanol from aqueous solutions [J]. Engineering in Life Sciences, 2021, 21(10): 653. https://doi.org/10.1002/ELSC.202000090 |
| [11] | Xie S, Zhang Y, Yi C, et al. Biobutanol recovery from model solutions using potassium pyrophosphate [J]. Journal of Chemical Technology and Biotechnology, 2017, 92(6): 1229-1235. https://doi.org/10.1002/jctb.5113 |
| [12] | Xie S, Yi C, Qiu X. Salting-out of acetone, 1-butanol, and ethanol from dilute aqueous solutions [J]. AIChE Journal, 2015, 61(10): 3470-3478. https://doi.org/10.1002/aic.14872 |
| [13] | Lei Z, Zhang J, Chen B. Separation of aqueous isopropanol by reactive extractive distillation [J]. Journal of Chemical Technology and Biotechnology, 2002, 77(11): 1251-1254. https://doi.org/10.1002/JCTB.700 |
| [14] | Anbarasan P, Baer Z C, Sreekumar S, et al. Integration of chemical catalysis with extractive fermentation to produce fuels [J]. Nature, 2012, 491(7423): 235-239. https://doi.org/10.1038/nature11594 |
| [15] | Xie S, Yi C, Qiu X. Salting-out effect of potassium pyrophosphate (K4P2O7) on the separation of biobutanol from an aqueous solution [J]. Journal of Chemical Technology & Biotechnology, 2016, 91(6): 1860-1867. https://doi.org/10.1002/JCTB.4779 |
| [16] | Kushwaha D, Upadhyay S N, Mishra P K. Nanotechnology in Bioethanol/Biobutanol Production [J]. 2018: 115-127. https://doi.org/10.1007/978-3-319-75052-1_8 |
| [17] | Xie S, Ji W, Zhang Y, et al. Biobutanol recovery from model solutions/fermentation broth using tripotassium phosphate [J]. Biochemical Engineering Journal, 2016, 115: 85-92. https://doi.org/10.1016/j.bej.2016.08.010 |
| [18] | Yi C, Xie S, Qiu X. Salting-out effect of dipotassium hydrogen phosphate on the recovery of acetone, butanol, and ethanol from a prefractionator [J]. Journal of Chemical and Engineering Data, 2014, 59(5): 1507-1514. https://doi.org/10.1021/je401060m |
| [19] | Kenters N, Huijskens E G W, De Wit S C J, et al. Effectiveness of cleaning-disinfection wipes and sprays against multidrug-resistant outbreak strains [J]. American Journal of Infection Control, 2017, 45(8): e69-e73. https://doi.org/10.1016/J.AJIC.2017.04.290 |
| [20] | Wiemken T L, Powell W, Carrico R M, et al. Disinfectant sprays versus wipes: Applications in behavioral health [J]. American Journal of Infection Control, 2016, 44(12): 1698-1699. https://doi.org/10.1016/J.AJIC.2016.05.028 |
| [21] | Voloshin R A, Rodionova M V., Zharmukhamedov S K, et al. Review: Biofuel production from plant and algal biomass [A]//International Journal of Hydrogen Energy. 2016: 17257-17273. https://doi.org/10.1016/j.ijhydene.2016.07.084 |
| [22] | Xie S, Yi C, Qiu X. Energy-saving recovery of acetone, butanol, and ethanol from a prefractionator by the salting-out method [J]. Journal of Chemical and Engineering Data, 2013, 58(11): 3297-3303. https://doi.org/10.1021/je400740z |
| [23] | Wang C, Zhang X, Zhao G, et al.. Mechanisms, methods and applications of machine learning in bio-alcohol production and utilization: A review [J]. Chemosphere, 2023, 342: 140191. https://doi.org/10.1016/j.chemosphere.2023.140191 |
| [24] | McMillan J D. Bioethanol production: Status and prospects [J]. Renewable Energy, 1997, 10(2-3): 295-302. https://doi.org/10.1016/0960-1481(96)00081-X |
| [25] | Cai H, Dunn J B, Wang Z, et al. Life-cycle energy use and greenhouse gas emissions of production of bioethanol from sorghum in the United States [J]. Biotechnology for Biofuels, 2013, 6(1): 1-15. https://doi.org/10.1186/1754-6834-6-141/TABLES/9 |
| [26] | Petrovič U. Next-generation biofuels: A new challenge for yeast [J]. Yeast, 2015, 32(9): 583-593. https://doi.org/10.1002/yea.3082 |
| [27] | Jabasingh S A, Lalith D, Prabhu M A, et al. Catalytic conversion of sugarcane bagasse to cellulosic ethanol: TiO2 coupled nanocellulose as an effective hydrolysis enhancer [J]. Carbohydrate Polymers, 2015, 136: 700-709. https://doi.org/10.1016/j.carbpol.2015.09.098 |
| [28] | Flickinger M C. Current Biological Research in Conversion of Cellulose Carbohydrates Into Liquid Fuels - How Far Have We Come? [J]. Biotechnology and Bioengineering, 1980. |
| [29] | Tan J, Sun Z, Huang H, et al. Salting-out: A novel purification technique in biorefinery [J]. Desalination, 2023, 564: 116790. https://doi.org/10.1016/J.DESAL.2023.116790 |
| [30] | Hans M, Lugani Y, Chandel A K, et al. Production of first- and second-generation ethanol for use in alcohol-based hand sanitizers and disinfectants in India [J]. Biomass Conversion and Biorefinery, 2023, 13(9): 7423-7440. https://doi.org/10.1007/S13399-021-01553-3/FIGURES/2 |
| [31] | Amanullah A, Kapilan R. Utilization of bioethanol generated from papaw peel waste for hand sanitizer production [J]. International Journal of Multidisciplinary Studies, 2021, 8(3): 101-124. |
| [32] | Bhuyar P, Sathyavathi S, Math R K, et al. Production of bioethanol from starchy tuber (Amorphophallus commutatus) and antimicrobial activity study of its extracts [J]. African Journal of Biological Sciences (South Africa), 2020, 2(2): 70-76. https://doi.org/10.33472/AFJBS.2.2.2020.70-76 |
| [33] | Jayakumar M, Kuppusamy Vaithilingam S, Karmegam N, et al. Bioethanol Production from Green Biomass Resources: Emerging Technologies [J]. Encyclopedia of Green Materials, 2025: 248-259. https://doi.org/10.1007/978-981-97-4618-7_110 |
| [34] | Lightfoot E N, Moscariello J S. Bioseparations [J]. Biotechnology and Bioengineering, 2004, 87(3): 259-273. https://doi.org/10.1002/bit.20111 |
| [35] | Walker G, Stewart G. Saccharomyces cerevisiae in the Production of Fermented Beverages [J]. Beverages, 2016. https://doi.org/10.3390/beverages2040030 |
| [36] | García V, Päkkilä J, Ojamo H, et al. Challenges in biobutanol production: How to improve the efficiency? [A]//Renewable and Sustainable Energy Reviews. 2011: 964-980. https://doi.org/10.1016/j.rser.2010.11.008 |
| [37] | Radakovits R, Jinkerson R E, Darzins A, et al. Genetic engineering of algae for enhanced biofuel production [A] // Eukaryotic Cell. 2010: 486-501. https://doi.org/10.1128/EC.00364-09 |
| [38] | Gong J, You F. Global optimization for sustainable design and synthesis of algae processing network for CO2 mitigation and biofuel production using life cycle optimization [J]. AIChE Journal, 2014, 60(9): 3195-3210. https://doi.org/10.1002/aic.14504 |
| [39] | Karp S G, Woiciechowski A L, Soccol V T, et al. Pretreatment strategies for delignification of sugarcane bagasse: A Review [J]. Brazilian Archives of Biology and Technology, 2013, 56(4): 679-689. https://doi.org/10.1590/S1516-89132013000400019 |
| [40] | Tao L, He X, Tan E C D, et al. Comparative techno-economic analysis and reviews of n-butanol production from corn grain and corn stover [J]. Biofuels, Bioproducts and Biorefining, 2014, 8(3): 342-361. https://doi.org/10.1002/BBB.1462 |
| [41] | Tao L, Milbrandt A, Zhang Y, et al. Techno-economic and resource analysis of hydroprocessed renewable jet fuel [J]. Biotechnology for Biofuels, 2017, 10(1): 1-16. https://doi.org/10.1186/S13068-017-0945-3/FIGURES/7 |
| [42] | Ma B, Tan J, Liu S, et al. Enhancing biofuel dewatering efficiency by ionizing food-additives-based salting-out agents [J]. Separation and Purification Technology, 2025, 354(P3): 128906. https://doi.org/10.1016/j.seppur.2024.128906 |
| [43] | Tan J, Huang H, Li H, et al. Biobutanol extraction and dehydration with eucalyptus oil yielding linear and cyclic biofuel blends [J]. AIChE Journal, 2024(March). https://doi.org/10.1002/aic.18495 |
| [44] | Xie S, Li Z, Luo S, et al. Bioethanol to jet fuel: Current status, challenges, and perspectives [J]. Renewable and Sustainable Energy Reviews, 2024, 192: 114240. https://doi.org/10.1016/j.rser.2023.114240 |
| [45] | Jones D T, Woods D R. Acetone-butanol fermentation revisited [J]. Microbiological Reviews, 1986, 50(4): 484-524. https://doi.org/10.1128/mmbr.50.4.484-524.1986 |
| [46] | Segovia-Hernandez J G, Vázquez-Ojeda M, Gómez-Castro F I, et al. Process control analysis for intensified bioethanol separation systems [J]. Chemical Engineering and Processing: Process Intensification, 2014, 75: 119-125. https://doi.org/10.1016/J.CEP.2013.11.002 |
| [47] | Khalid A, Aslam M, Qyyum M A, et al. Membrane separation processes for dehydration of bioethanol from fermentation broths: Recent developments, challenges, and prospects [J]. Renewable and Sustainable Energy Reviews, 2019, 105: 427-443. https://doi.org/10.1016/J.RSER.2019.02.002 |
| [48] | Sun Z, Tan J, Zhou G, et al. Sugaring-out plus salting-out: A novel separation and purification technique for biofuel [J]. Fuel, 2024, 357: 129787. https://doi.org/10.1016/J.FUEL.2023.129787 |
| [49] | Vane L M. Separation technologies for the recovery and dehydration of alcohols from fermentation broths [A]//Biofuels, Bioproducts and Biorefining. 2008: 553-588. https://doi.org/10.1002/bbb.108 |
| [50] | Fu C, Li Z, Song W, et al. A new process for separating biofuel based on the salt + 1-butanol + water system [J]. Fuel, 2020, 278: 118402. https://doi.org/10.1016/j.fuel.2020.118402 |
| [51] | Haider J, Qyyum M A, Hussain A, et al. Techno-economic analysis of various process schemes for the production of fuel grade 2,3-butanediol from fermentation broth [J]. Biochemical Engineering Journal, 2018. https://doi.org/10.1016/j.bej.2018.09.002 |
| [52] | Xie S, Sun Z, Tan J, et al. Emerging Micromolecule-based Aqueous Two-phase Systems and Their Application in Biofuels [J]. Innovation Discovery, 2024, 1(4): 30. https://doi.org/10.53964/id.2024030 |
| [53] | Xie S, Li Z, Zhu G. Salting-out Effect on the Separation and Purification of Acetic Esters: Salting-out Agents, Theory, and Applications [J]. Separation and Purification Reviews, 2022. https://doi.org/10.1080/15422119.2022.2159837 |
| [54] | Xie S, Li Z, Zhu G, et al. Cleaner production and downstream processing of bio-based 2,3-butanediol: A review [J]. Journal of Cleaner Production, 2022, 343: 131033. https://doi.org/10.1016/j.jclepro.2022.131033 |
| [55] | Fu C, Li Z, Sun Z, et al. A review of salting-out effect and sugaring-out effect: Driving forces for novel liquid-liquid extraction of biofuels and biochemicals [J]. Frontiers of Chemical Science and Engineering, 2020, 15: 854–871. https://doi.org/10.1007/s11705-020-1980-3 |
| [56] | Fu C, Xie S. Salts and 1-propanol induced aqueous two-phase systems: phase separation and application [J]. Journal of Chemical Technology and Biotechnology, 2019, 94(7): 2372-2381. https://doi.org/10.1002/jctb.6036 |
| [57] | Fu C, Song W, Yi C, et al. Creating efficient novel aqueous two-phase systems: Salting-out effect and high solubility of salt [J]. Fluid Phase Equilibria, 2019, 490: 77-85. https://doi.org/10.1016/j.fluid.2019.03.002 |
| [58] | Boyce J M. Alcohols as Surface Disinfectants in Healthcare Settings [J]. Infection Control & Hospital Epidemiology, 2018, 39(3): 323-328. https://doi.org/10.1017/ICE.2017.301 |
| [59] | Chichango F, Cristóvão L. Review of literature on methods and processes to produce bioethanol from banana peels for disinfection and sanitation of the environment in communities, central region of Mozambique [J]. Research, Society and Development, 2024, 13(3): e12713344921-e12713344921. https://doi.org/10.33448/RSD-V13I3.44921 |
| [60] | Kusumawati N, Setiarso P, Santoso A B, et al. Expansion of Hand Hygiene Compliance and Decreasing Counterfeiting of Sanitation Products in the Era of the COVID-19 through Diversification and Standardization of Alcohol-Based Gel and Wipes Hand Sanitizer [J]. International Journal on Advanced Science, Engineering and Information Technology, 2022, 12(1): 411-422. https://doi.org/10.18517/ijaseit.12.1.13940 |
| [61] | Ulep R A, Madigal J P T, Suarez T C E, et al. “Nipahol”: A Locally Formulated Sanitizer/Disinfectant from Nipa Bioethanol for Possible Use Against Covid-19 [J]. Agro Bali : Agricultural Journal, 2021, 5(1): 30-41. https://doi.org/10.37637/AB.V5I1.839 |
| [62] | Setiarso P, Kusumawati N, Santoso A B, et al. Production standardization of hand sanitizer spray based on ethanol, isopropanol, and bioethanol to prevent the COVID-19 transmission [J]. AIP Conference Proceedings, 2022, 2645. https://doi.org/10.1063/5.0130873 |
| [63] | Zhang Q, Dong J, Liu Y, et al. Towards a green bulk-scale biobutanol from bioethanol upgrading [J]. Journal of Energy Chemistry, 2016, 25(6): 907-910. https://doi.org/10.1016/J.JECHEM.2016.08.010 |
| [64] | Taylor J D, Jenni M M, Peters M W. Dehydration of fermented isobutanol for the production of renewable chemicals and fuels [C]//Topics in Catalysis. 2010. https://doi.org/10.1007/s11244-010-9567-8 |
| [65] | Baez A, Cho K M, Liao J C. High-flux isobutanol production using engineered Escherichia coli: A bioreactor study with in situ product removal [J]. Applied Microbiology and Biotechnology, 2011. https://doi.org/10.1007/s00253-011-3173-y |
| [66] | Balat M, Balat H, Öz C. Progress in bioethanol processing [J]. Progress in Energy and Combustion Science, 2008, 34(5): 551-573. https://doi.org/10.1016/J.PECS.2007.11.001 |
| [67] | Taylor G. Biofuels and the biorefinery concept [J]. Energy Policy, 2008. https://doi.org/10.1016/j.enpol.2008.09.069 |
| [68] | Ibrahim M F, Ramli N, Kamal Bahrin E, et al. Cellulosic biobutanol by Clostridia: Challenges and improvements [J]. Renewable and Sustainable Energy Reviews, 2017, 79: 1241-1254. https://doi.org/10.1016/J.RSER.2017.05.184 |
| [69] | Balat M, Balat H. Recent trends in global production and utilization of bio-ethanol fuel [J]. Applied Energy, 2009, 86(11): 2273-2282. https://doi.org/10.1016/j.apenergy.2009.03.015 |
| [70] | Harvey B G, Merriman W W, Koontz T A. High-density renewable diesel and jet fuels prepared from multicyclic sesquiterpanes and a 1-hexene-derived synthetic paraffinic kerosene [J]. Energy and Fuels, 2015, 29(4): 2431-2436. https://doi.org/10.1021/ef5027746 |
| [71] | Tao L, Foust T D. Biorefinery ethanol upgrading: Opportunities and challenges [J]. Joule, 2021, 5(3): 524-526. https://doi.org/10.1016/J.JOULE.2021.02.014 |
