新型多靶点协同调控技术在皮肤抗衰与屏障修护中的创新应用
1. 广州市欧俐化妆品有限公司, 研发部, 广东广州 510800
2. 中科健兰医学研究院, 皮肤健康研究中心, 北京 101407
3. 上合医学研究院, 皮肤医学研究部, 北京 100094
| 摘 要： | 随着皮肤生理学与生物工程技术的发展，功能性护肤已从单一靶点干预向多靶点协同调控方向转型，皮肤美白淡斑、抗衰紧致与屏障修护成为当代皮肤健康研究的核心热点。皮肤老化与色素沉着受紫外线照射、氧化应激、蛋白糖化、屏障受损等多因素协同驱动，单一作用靶点的干预手段难以解决复杂的皮肤健康问题。本文系统综述多靶点协同调控技术的核心原理、活性成分作用机制、配方设计原则及功效评价方法，重点探讨中国科学院与中科健兰联合尚清欧俐共同开发的新型华伊世家系列皮肤抗衰技术的创新实践。该技术通过烟酰胺、蓝宝石褪黑藻、凝血酸等活性成分复配实现黑色素全链路调控；以逆龄因子、肌肽及信号肽类成分构建”再生-保护-调控”三重抗衰体系；以纤连蛋白、芦荟仙人掌发酵液及植物提取物协同强化屏障修护。体外细胞试验与临床观察表明，该技术可显著抑制黑色素细胞活性、促进成纤维细胞增殖与胶原合成，连续使用28天可显著改善肤色暗沉、色斑、细纹及屏障受损等问题。 本文同时探讨多机构协同创新模式在皮肤健康干预领域的应用，为皮肤美白抗衰与屏障修护技术的高效化、温和化、合规化发展提供理论参考与实践借鉴。 |
| 关 键 词： | 多靶点; 协同调控; 皮肤抗衰; 屏障修护 |
| DOI： | 10.57237/j.mrf.2026.01.002 |
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收稿日期: 2026-04-16
接受日期: 2026-05-22
在线出版日期: 2026-05-28
Innovative Application of a Novel Multi-Target Synergistic Regulation Technology in Skin Anti-Aging and Barrier Repair
1. Department of R&D, Guangzhou Ouli Cosmetics Co., Ltd., Guangzhou 510800, China
2. Science Division, Zhongke Bio-Manufacturing Innovation Center, Beijing 100094, China
| Abstract: | With the development of skin physiology and bioengineering technology, functional skin care has transformed from single-target intervention to multi-target synergistic regulation. Skin whitening and spot lightening, anti-aging and firming, and barrier repair have become the core hotspots in contemporary skin health research. Skin aging and pigmentation are synergistically driven by multiple factors such as ultraviolet radiation, oxidative stress, protein glycosylation, and barrier damage. Intervention methods targeting a single action site are difficult to solve complex skin health problems. This paper systematically reviews the core principles of multi-target synergistic regulation technology, the mechanism of action of active ingredients, the principles of formula design, and methods of efficacy evaluation, with a focus on the innovative practice of the novel Huayi Shijia series skin anti-aging technology jointly developed by the Chinese Academy of Sciences and Zhongke Jianlan in collaboration with Shangqing Ouli. This technology achieves full-chain regulation of melanin through the compounding of niacinamide, sapphire algae extract, and tranexamic acid; constructs a triple anti-aging system of “regeneration-protection-regulation” using anti-aging factors, carnosine, and signal peptides; and synergistically strengthens barrier repair through fibronectin, aloe-cactus fermentation broth, and plant extracts. In vitro cell experiments and clinical observations demonstrate that this technology can significantly inhibit melanocyte activity, promote fibroblast proliferation and collagen synthesis, and continuous use for 28 days can significantly improve skin dullness, pigmentation, fine lines, and barrier damage. This paper also discusses the application of the multi-institution collaborative innovation model in the field of skin health intervention, providing theoretical reference and practical experience for the efficient, mild, and compliant development of skin whitening, anti-aging, and barrier repair technologies. |
| Keywords: | Multi-target; Synergistic Regulation; Skin Anti-aging; Barrier Repair |
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