RNA结合基序蛋白通过调控基因表达影响肿瘤进展
中国人民解放军联勤保障部队第九四〇医院, 耳鼻咽喉头颈外科, 甘肃兰州 730000
| 摘 要： | RNA结合基序（RNA binding motif, RBM）蛋白是一种RNA结合蛋白（RNA binding proteins, RBP），其与细胞中的大量功能都密切相关，在细胞信号转导、基因表达和机体代谢等多个层面参与各种生理病理过程，由于其在生物体内表达广泛且稳定而被研究人员广泛关注。近年来，许多研究者发现RBM家族参与pre-mRNA的剪接，并且在维持剪接体催化核心构象方面起着重要作用，同时在催化核心与剪接体其他必需蛋白组分之间起着桥梁作用。正是由于其广泛的基因表达调控范围，RBM蛋白家族与自身免疫病、炎症以及多种癌症相关，许多研究表明其可能成为各类疾病的治疗靶点。本文就RBM蛋白家族的作用及机制（尤其在肿瘤当中）作一综述，为相关疾病的治疗和预后提供参考。 |
| 关 键 词： | RBM蛋白; 肿瘤; 研究机制 |
| DOI： | 10.57237/j.mrf.2025.01.001 |
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收稿日期: 2024-11-25
接受日期: 2025-01-18
在线出版日期: 2025-03-13
RNA-binding Motif Proteins Influence Tumour Progression by Regulating Gene Expression
Department of Otorhinolaryngology, Head and Neck Surgery, No. 940 Hospital of the Joint Logistics and Security Force of the Chinese People's Liberation Army, Lanzhou 730000, China
| Abstract: | RNA binding motif (RBM) proteins are a class of RNA binding proteins, It's involved in a lot of functions in cells, they are involved in various physiological and pathological processes at multiple levels such as cell signal transduction, gene expression and body metabolism. They have been widely concerned by researchers due to their wide and stable expression in organisms. In recent years, many researchers have found that the RBM family is involved in the splicing of pre-mRNA, and plays an important role in maintaining the conformation of the catalytic core of the splicosome, and also acts as a bridge between the catalytic core and other essential protein components of the splicosome. Because of its wide range of gene expression regulation, the RBM protein family is associated with autoimmune diseases, inflammation and a variety of cancers, Many studies have shown that RBM protein family may be a therapeutic target for various diseases. This article reviews the role and mechanism of RBM protein family, especially in tumors, and provides reference for the treatment and prognosis of related diseases. |
| Keywords: | RBM Protein Family; Cancer; Research Mechanism |
基金
| 1. | 省级青年科技基金 (批准No. 20JR10RA011) |
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