鼻内翻乳头状瘤研究进展
1. 甘肃中医药大学, 第一临床医学院, 甘肃兰州 730000
2. 联勤保障部队第940医院, 耳鼻咽喉头颈外科学, 甘肃兰州 730000
| 摘 要： | 鼻内翻乳头状瘤是一种鼻部良性肿瘤，因其在组织学上特有的内生性的生长模式而得名，具有骨重塑和破坏、局部复发和恶性肿瘤相关的局部侵袭性三大特点。其组织学特征是上皮增生，鳞状上皮细胞呈指状增生到下面的间质中，向下生长成先前存在的粘膜腺体，取代或者是替代正常上皮。关于比内翻乳头状瘤的病因至今仍不清楚，大部分研究认为可能与HPV感染、吸烟以及职业暴露有关。随着现代内窥镜检查以及CT、MRI技术的飞速发展，对于IP的诊断也越来越精确。手术治疗和内窥镜下治疗是对IP主要的治疗方式，但是对于一些分期较高的患者，我们临床医生一定要注重IP复发的可能。 |
| 关 键 词： | 鼻窦内翻乳头状瘤; 人乳头瘤病毒; 手术治疗; 病理研究 |
| DOI： | 10.57237/j.mrf.2024.04.002 |
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收稿日期: 2024-10-24
接受日期: 2024-11-27
在线出版日期: 2025-01-09
Advances in the Study of Intranasal Turning Papillomas
1. The First Clinical Medical College, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China
2. Otorhinolaryngology, Head and Neck Surgery, No. 940 Hospital of Joint Command and Guarantee Force, Lanzhou 730000, China
| Abstract: | Nasal invasive papilloma is benign tumor named for its characteristic histologic endophytic growth pattern with three major features: bone remodeling and destruction, local recurrence, and local aggressiveness associated with malignancy. It is histologically characterized by epithelial proliferation, with squamous epithelial cells proliferating finger-like into the underlying mesenchyme and growing downward into pre-existing mucosal glands, replacing or substituting for normal epithelium. The etiology of bigness papilloma is still unclear and most studies suggest that it may be related to HPV infection, smoking, and occupational exposure. With the rapid development of modern endoscopy and CT and MRI techniques, the diagnosis of IP is becoming more accurate. Surgery is the main treatment modality for IP, but for some patients with higher staging, our clinicians must focus on the possibility of IP recurrence. |
| Keywords: | Inverted Papillomas (IP); HPV; Surgical Treatment; Pathology Research |
基金
| 1. | 2021年甘肃省部基金 (基金号: No. 20JR10R013) |
参考文献
| [1] | Wood J W, Casiano R R. Inverted papillomas and benign nonneoplastic lesions of the nasal cavity [J]. Am J Rhinol Allergy, 2012, 26(2): 157-163. |
| [2] | Chiu A G, Jackman A H, Antunes M B, et al. Radiographic and histologic analysis of the bone underlying inverted papillomas [J]. Laryngoscope, 2006, 116(9): 1617-1620. |
| [3] | Lee J J, Roland L T, Licata J J, et al. Morphologic, intraoperative, and histologic risk factors for sinonasal inverted papilloma recurrence [J]. Laryngoscope, 2020, 130(3): 590-596. |
| [4] | Yiotakis J, Hantzakos A, Kandiloros D, et al. A rare location of bilateral inverted papilloma of the nose and paranasal sinuses [J]. Rhinology, 2002, 40(4): 220-222. |
| [5] | Cavada M N, Roshan D J, Lodhia C A, et al. The inverted papilloma arising from the cribriform plate of the ethmoid bone [J]. ANZ J Surg, 2023, 93(3): 707-709. |
| [6] | Maurizi R, Gubari M, Yazan A S, et al. Inverted papilloma with bilateral origin. A case report and review of the literature [J]. Ann Ital Chir, 2022, 11. |
| [7] | Gupta R, Rady P L, Sikora A G, et al. The role of human papillomavirus in the pathogenesis of sinonasal inverted papilloma: a narrative review [J]. Rev Med Virol, 2021, 31(3): e2178. |
| [8] | Doddawad V G, Premalatha B R, Sreeshyla H S, et al. Classification staging systems on clinical and radiographic features of inverted sinonasal papilloma: A case report [J]. Oral Oncol, 2022, 127: 105768. |
| [9] | Ringertz N. Pathology of malignant tumors arising in the nasal and paranasal cavities and maxilla [J]. Acta Otolaryngol, 1938, 27: 31-42. |
| [10] | Thompson L. World Health Organization classification of tumours: pathology and genetics of head and neck tumours [J]. Ear Nose Throat J, 2006, 85(2): 74. |
| [11] | Syrjänen S, Happonen R P, Virolainen E, et al. Detection of human papillomavirus (HPV) structural antigens and DNA types in inverted papillomas and squamous cell carcinomas of the nasal cavities and paranasal sinuses [J]. Acta Otolaryngol, 1987, 104(3-4): 334-341. |
| [12] | Ferreli F, Di Bari M, Moya-Plana A, et al. Association between human papillomavirus infection and malignant transformation of sinonasal inverted papilloma: A systematic review and meta-analysis [J]. Am J Otolaryngol, 2022, 43(6): 103614. |
| [13] | Zhao R W, Guo Z Q, Zhang R X. Human papillomavirus infection and the malignant transformation of sinonasal inverted papilloma: A meta-analysis [J]. J Clin Virol, 2016, 79: 36-43. |
| [14] | Syrjänen K, Syrjänen S. Detection of human papillomavirus in sinonasal papillomas: systematic review and meta-analysis [J]. Laryngoscope, 2013, 123(1): 181-192. |
| [15] | Udager A M, McHugh J B, Goudsmit C M, et al. Human papillomavirus (HPV) and somatic EGFR mutations are essential, mutually exclusive oncogenic mechanisms for inverted sinonasal papillomas and associated sinonasal squamous cell carcinomas [J]. Ann Oncol, 2018, 29(2): 466-471. |
| [16] | Liu Y, Duan L, Tian J, et al. Role of the Akt/mTOR signaling pathway in human papillomavirus-associated nasal and sinonasal inverted papilloma [J]. Acta Biochim Biophys Sin (Shanghai), 2017, 49(12): 1067-1074. |
| [17] | Menendez M, Cabal V N, Vivanco B, et al. Loss of p16 expression is a risk factor for recurrence in sinonasal inverted papilloma [J]. Rhinology, 2022, 60(6): 453-461. |
| [18] | Wang M J, Noel J E. Etiology of sinonasal inverted papilloma: A narrative review [J]. World J Otorhinolaryngol Head Neck Surg, 2017, 3(1): 54-58. |
| [19] | Nishino K, Sekine M, Kodama S, et al. Cigarette smoking and glutathione S-transferase M1 polymorphism associated with risk for uterine cervical cancer [J]. J Obstet Gynaecol Res, 2008, 34(6): 994-1001. |
| [20] | Moon I J, Lee D Y, Suh M W, et al. Cigarette smoking increases risk of recurrence for sinonasal inverted papilloma [J]. Am J Rhinol Allergy, 2010, 24(5): 325-329. |
| [21] | D'Errico A, Zajacova J, Cacciatore A, et al. Occupational risk factors for sinonasal inverted papilloma: a case-control study [J]. Occup Environ Med, 2013, 70(10): 703-708. |
| [22] | Sham C L, Lee D L, van Hasselt C A, et al. A case-control study of the risk factors associated with sinonasal inverted papilloma [J]. Am J Rhinol Allergy, 2010, 24(1): e37-e40. |
| [23] | He X, Wang Y. Clinical characteristics of sinonasal inverted papilloma associated with recurrence and malignant transformation [J]. Auris Nasus Larynx, 2021, 48(6): 1105-1108. |
| [24] | Wright E J, Chernichenko N, Ocal E, et al. Benign inverted papilloma with intracranial extension: prognostic factors and outcomes [J]. Skull Base Rep, 2011, 1(2): 145-150. |
| [25] | Visvanathan V, Wallace H, Chumas P, et al. An unusual presentation of inverted papilloma: case report and literature review [J]. J Laryngol Otol, 2010, 124(1): 101-104. |
| [26] | Jiang J, Xiao Z, Tang Z, et al. Differentiating between benign and malignant sinonasal lesions using dynamic contrast-enhanced MRI and intravoxel incoherent motion [J]. Eur J Radiol, 2018, 98: 7-13. |
| [27] | Li Z, Xian M, Guo J, et al. Dynamic Contrast-Enhanced MRI Can Quantitatively Discriminate the Original Site From Peripheral Portion of Sinonasal Inverted Papillomas [J]. J Magn Reson Imaging, 2021, 53(5): 1522-1527. |
| [28] | Li Z, Xian M, Guo J, et al. Dynamic contrast-enhanced MRI can quantitatively identify malignant transformation of sinonasal inverted papilloma [J]. Br J Radiol, 2022, 95(1134): 20211374. |
| [29] | Krouse J H. Development of a staging system for inverted papilloma [J]. Laryngoscope, 2000, 110(6): 965-968. |
| [30] | Lisan Q, Moya-Plana A, Bonfils P. Association of Krouse Classification for Sinonasal Inverted Papilloma With Recurrence: A Systematic Review and Meta-analysis [J]. JAMA Otolaryngol Head Neck Surg, 2017, 143(11): 1104-1110. |
| [31] | Han J K, Smith T L, Loehrl T, et al. An evolution in the management of sinonasal inverting papilloma [J]. Laryngoscope, 2001, 111(8): 1395-1400. |
| [32] | Cannady S B, Batra P S, Sautter N B, et al. New staging system for sinonasal inverted papilloma in the endoscopic era [J]. Laryngoscope, 2007, 117(7): 1283-1287. |
| [33] | Chaskes M B, Lee Y E, Toskala E, et al. Unique volatile metabolite signature of sinonasal inverted papilloma detectable in plasma and nasal secretions [J]. Int Forum Allergy Rhinol, 2022, 12(10): 1254-1262. |
| [34] | Trent M S, Goshtasbi K, Hui L, et al. A Systematic Review of Definitive Treatment for Inverted Papilloma Attachment Site and Associations With Recurrence [J]. Otolaryngol Head Neck Surg, 2022, 167(3): 425-433. |
| [35] | Goudakos J K, Blioskas S, Nikolaou A, et al. Endoscopic Resection of Sinonasal Inverted Papilloma: Systematic Review and Meta-Analysis [J]. Am J Rhinol Allergy, 2018, 32(3): 167-174. |
| [36] | Litzistorf Y, Gorostidi F, Lambercy K, et al. Utility of flexible interventional endoscopy in endoscopic sinus surgery: a case series [J]. Eur Arch Otorhinolaryngol, 2023, 280(3): 1231-1239. |
| [37] | Liu F, Ye F, Gu X, et al. Dynamic Incision under Nasal Endoscope and Low-Temperature Plasma Radiofrequency Ablation for Nasal Inverted Papilloma: An Analysis of Differences in Efficacy and the Destructive Effect on Immune Function [J]. Comput Math Methods Med, 2022, 2022: 9618193. |
| [38] | Giombi F, Di Santo D, Spriano G, et al. Applications of Co(2) laser in endoscopic surgery for sinonasal neoplasms [J]. Am J Otolaryngol, 2022, 43(3): 103281. |
