基于Markov模型探究高血压药物治疗的经济学评价
广西中医药大学, 赛恩斯新医药学院医学系, 南宁 530222
| 摘 要： | 目的：对天麻钩藤饮加减辅助治疗高血压和仅使用常规西药治疗高血压两种方案进行长期经济学评价，为高血压的干预药物提供合理依据。方法：从医疗保障支付方角度出发，以天麻钩藤饮加减联合降压药治疗高血压的最新临床研究结果作为数据来源构建Markov模型，通过模型模拟疾病的发生发展，分析两种方案治疗高血压的成本和效用，之后进行敏感性分析，查看结果的稳定性。结果：天麻钩藤饮加减联合常规西药治疗20年后累计成本为56865.29元，卫生产出为10.38 QALYs；仅使用西药治疗20年后的累计成本为5813.91元，卫生产出为9.62 QALYs，ICER为51051.38元/QALY。敏感性分析显示，单向和概率敏感性分析显示在可接受范围内结果不变，不影响模型结果，表明经济性良好，可以进行使用。结论：天麻钩藤饮加减联合降压药治疗高血压可作为较好的治疗方案，具有较好的健康改善和经济学效果，可在临床中广泛应用。 |
| 关 键 词： | 中药; 天麻钩藤饮加减; 决策树; 马尔科夫模型; 成本-效果分析 |
| DOI： | 10.57237/j.mrf.2024.02.002 |
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收稿日期: 2024-02-27
接受日期: 2024-05-13
在线出版日期: 2024-05-23
Exploring the Economic Evaluation of Pharmacological Treatment of Hypertension Based on Markov Modeling
Department of Medicine, Faculty of Chinese Medicine Science Guangxi University of Chinese Medicine, Nanning 530222, China
| Abstract: | Objective: To conduct long-term economic evaluation of two adjuvant treatments of Gastroma Guteng Yin in the treatment of hypertension and only using conventional western medicine in the treatment of hypertension, so as to provide reasonable basis for intervention drugs for hypertension. Methods: From the perspective of Medicare payers, a Markov model was constructed using the results of the latest clinical studies on the treatment of hypertension with the addition of Tianma Hook Teng Drink combined with antihypertensive drugs as a source of data, through which the development of the disease was simulated, and the cost and utility of the two regimens for the treatment of hypertension were analyzed, after which sensitivity analyses were performed to check the stability of the results. Results: The cumulative cost after 20 years of treatment with Tianma Hook Teng Drink Plus in combination with conventional western medicines was $56,865.29, with a health output of 10.38 QALYs, while the cumulative cost after 20 years of treatment with western medicines only was $5813.91, with a health output of 9.62 QALYs, and an ICER of $51,051.38/QALY. Sensitivity analysis showed that unidirectional and probabilistic sensitivity analysis showed that the results remained unchanged within the acceptable range and did not affect the model results, indicating that the economy was good and could be used. Conclusion: Gastroma Guteng Yin combined with antihypertensive drugs can be used as a better treatment for hypertension, which has good health improvement and economic effects, and can be widely used in clinic. |
| Keywords: | Traditional Chinese Medicine; Gastrodia Guoteng Yin Plus or Minus; Decision Tree; Markov Model; Cost-Effectiveness Analysis |
基金
| 1. | 国家自然科学基金项目 (编号: 82204755, 81960751) |
| 2. | 广西中医药大学赛恩斯新医药学院科研项目 (编号: 2022CX004, 2022MS008, 2022QJ001) |
| 3. | 广西中医药大学赛恩斯新医药学院国家级大学生创新训练项目 (202313643007) |
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