NLRP3在运动与代谢综合征炎症反应中的研究进展
1. 江西师范大学, 体育学院, 江西南昌 330027
2. 井冈山大学, 体育学院, 江西吉安 343009
| 摘 要： | 腺苷酸活化蛋白激酶（Amp-activated protein kinase, AMPK）是细胞糖脂代谢的重要调节剂，参与各种疾病的炎症和氧化应激，与核苷酸结合的低聚结构域样受体家族密切相关。AMPK信号通路的激活阻止了NLRP3炎症小体的组装与激活，炎症小体是一系列蛋白质复合物，介导下游炎症因子白细胞介素-18（IL-18）和白细胞介素1β（IL-1β）的成熟与释放，导致细胞的凋亡，引起一系列的炎症反应。AMPK通过激活氧化和增加葡萄糖和脂肪酸的摄取来增强细胞对能量的利用；因此，AMPK活性的破坏可能导致细胞能量的破坏和代谢紊乱从而导致炎症。而炎症通过各种机制参与到代谢综合征（metabolic syndromes, MS）中，炎症机制成为MS发病机制中一个重要的研究方向。运动已被证明在调节炎症方面发挥着重要作用，但运动调节炎症小体激活的机制尚不清楚。因此，研究运动对代谢综合征的影响是否是通过AMPK-NLRP3的转导机制来实现，可以为炎症小体相关的代谢性疾病的治疗提供科学的理论依据和新的治疗靶点。 |
| 关 键 词： | 炎症; 代谢综合征; NLRP3炎症小体; 运动; AMPK |
| DOI： | 10.57237/j.mrf.2024.01.002 |
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收稿日期: 2024-02-18
接受日期: 2024-03-15
在线出版日期: 2024-03-18
Advances in the Study of NLRP3 in the Inflammatory Response to Exercise and Metabolic Syndrome
1. School of Physical Education, Jiangxi Normal University, Nanchang 330027, China
2. School of Physical Education, Jinggangshan University, Ji'an 343009, China
| Abstract: | AMPK is an important regulator of cellular glycolipid metabolism and is in-volved in inflammation and oxidative stress in various diseases. AMPK is closely related to a family of nucleotide-binding oligomeric domain-like receptors, and activation of the AMPK signaling pathway prevents the assembly and activation of NLRP3 inflammatory vesicles, inflammatory vesicles are a series of protein complexes that mediate the maturation and release of the downstream inflammatory factors interleukin-18 (IL-18) and interleukin 1β (IL-1β), leading to apoptosis and causing a series of inflammatory responses. AMPK enhances cellular utilization of energy by activating oxidation and increasing uptake of glucose and fatty acids; there-fore, disruption of AMPK activity may lead to cellular Energy destruction and metabolic disorders leading to inflammation, which is involved in metabolic syndromes (MS) through various mechanisms, and inflammatory mechanisms have become an important research direction in the pathogenesis of MS; exercise has been shown to play a key role in regulating inflammation, but the mechanisms by which exercise regulates inflammatory vesicle activation are largely un-known. Therefore, investigating whether the effects of exercise on metabolic syndrome are mediated through AMPK-NLRP3 transduction mechanisms could provide a scientific rationale and new therapeutic targets for the treatment of metabolic diseases associated with inflammatory vesicles. |
| Keywords: | Inflammation; Metabolic Syndrome; NLRP3 Inflammatory Vesicles; Exercise; AMPK |
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