甲基苯丙胺滥用危害及药物干预的研究进展
1. 昆明医科大学第一附属医院, 科研实验中心, 云南昆明 650032
2. 昆明医科大学第一附属医院, 医学检验科, 云南昆明 650032
3. 昆明医科大学第一附属医院, 生殖遗传科, 云南昆明 650032
| 摘 要： | 在中国乃至全世界，毒品的滥用始终呈泛滥的趋势。甲基苯丙胺（methamphetamine，METH）已成为中国吸食人员最多的一种新型毒品。滥用甲基苯丙胺历史较为久远，其引起兴奋和致幻的特点对吸食者带来较为严重的后果，具体反映在对吸食者的神经、心血管和消化系统等造成严重损伤。神经系统的异常使得吸食者对该药物具有较强的依赖性，因此针对METH滥用的药物干预治疗成为了医疗界和社会需迫切解决的问题。到目前为止，已有多种合成西药以及传统中成药被证实在治疗和改善甲基苯丙胺滥用患者的成瘾依赖、调节神经和消化系统方面具有重要作用，本文将以滥用METH对造成机体危害的相关机制为切入点，针对药物在干预和改善吸食者机体组织器官，调控相关的分子机制中的具体作用，进行简要的综述。 |
| 关 键 词： | 甲基苯丙胺; 滥用危害; 组织损伤; 合成药调节; 中成药改善 |
| DOI： | 10.57237/j.mrf.2023.02.002 |
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收稿日期: 2022-10-22
接受日期: 2022-11-15
在线出版日期: 2023-04-25
The Harm of Methamphetamine Abuse and Studies of Drug Interventions
1. Scientific Research Laboratory Center, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
2. Department of Clinical Laboratory, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
3. Department of Genetics and Reproduction, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
| Abstract: | The trend of drug abuse is widespread in the world. As a new type of drug, methamphetamine (METH) has been taken by most abusers in China. There was a long methamphetamine abusing history until now, it could cause excitatory and hallucinogenic and bring serious consequences to the abusers. The consequence of methamphetamine abuse reflected in a serious damage to the nervous system, cardiovascular system and digestive system of abusers, the abnormal nervous system made abusers have strong dependence on this drug. Therefore, drug intervention to METH abuse has become an urgent problem to medical community and society. By now, there have been a variety of synthesis researches worked on western medicines and Chinese tradition medicines, which confirmed that they played important role in inhibiting dependence of methamphetamine abuse addiction, regulating or restoring the normal function of nervous and digestive systems. This study will take the relative mechanism of METH abuse causing body harm as the breakthrough point, then give a brief overview to aim at the specific role of drug intervention to the improvement of body's tissues and organs, and the regulation of related molecular mechanisms. |
| Keywords: | Methamphetamine; Harm of Abuse; Tissue Damage; Regulation of Synthesis Medicine; Restoration of Chinese Traditional Medicine |
基金
| 1. | 云南省教育厅科学研究基金项目《参苓白术散对甲基苯丙胺介导小鼠肠损伤治疗及肠道微生物调节机制》 (2022J0224) |
| 2. | 云南省卫生厅项目 (2017NS002和2018NS084) |
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