microRNAs与微囊藻毒素诱导的机体免疫紊乱
1. 安徽医科大学, 公共卫生学院, 安徽合肥 230032
2. 安徽医学高等专科学校, 医学技术学院, 安徽合肥 230601
| 摘 要： | 研究背景：水体富营养化导致的蓝藻水华不仅可以恶化水体环境，而且一些有毒的蓝藻水华大量繁殖还会产生蓝藻毒素。微囊藻毒素是世界范围内水库中发现的最丰富的蓝藻毒素之一，在其异构体中微囊藻毒素-亮氨酸精氨酸（MC-LR）是含量最多、毒性最强的变种，各种实验已经明确表明MC-LR具有肝毒性及致癌性，但其免疫损伤作用的研究还相对较少。大量研究已经表明microRNAs（miRNAs）参与了广泛的生物学过程，那miRNAs是否在微囊藻毒素暴露引起的机体免疫紊乱中也发挥作用？这是本研究要探讨的问题。研究目的：通过综述微囊藻毒素对机体免疫系统的影响、微囊藻毒素暴露引起miRNAs的改变以及miRNAs在免疫调节中的作用，进一步探索miRNAs在微囊藻毒素暴露诱导的机体免疫紊乱中可能发挥的重要作用。研究方法：首先收集微囊藻毒素对免疫系统影响的证据，接着对微囊藻毒素暴露对microRNAs表达的影响进行综述，最后探索microRNAs在免疫调节中的作用。研究结论：微囊藻毒素无论是暴露于体外还是体内都会引起miRNAs的表达发生改变，同时也会引起机体免疫系统做出相应反应，已有证据表明miRNAs参与了机体多种免疫调节过程，但关于miRNAs在藻毒素暴露引起的机体免疫紊乱中的研究仍相对较少。 |
| 关 键 词： | 微囊藻毒素; miRNAs; 免疫紊乱 |
| DOI： | 10.57237/j.mrf.2023.02.001 |
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收稿日期: 2023-03-10
接受日期: 2023-04-20
在线出版日期: 2023-04-25
MicroRNAs and Microcystins Induce Immune Disorders
1. School of Public Health, Anhui Medical University, Hefei 230032, China
2. School of Medical Technology, Anhui Medical College, Hefei 230601, China
| Abstract: | Background: Cyanobacterial blooms caused by eutrophication can not only worsen the water environment, but also produce cyanobacterial toxins when some toxic cyanobacterial blooms proliferate. Microcystin is one of the most abundant cyanobacterial toxins found in reservoirs worldwide. Among its isomer, microcystin-leucine-arginine (MC-LR) is the most abundant and most toxic variety. Various experiments have clearly shown that MC-LR has hepatotoxicity and carcinogenicity, but there are relatively few studies on its immune damage effect. Numerous studies have shown that microRNAs (miRNAs) are involved in a wide range of biological processes. Do miRNAs also play a role in immune disorders caused by microcystin exposure? This is the question to be discussed in this study. Objective: By reviewing the effects of microcystins on the immune system, the changes of miRNAs caused by microcystins exposure and the role of miRNAs in immune regulation, we further explore the possible important role of miRNAs in immune disorders induced by microcystins exposure. Methods: Firstly, evidence of the influence of microcystin on immune system was collected, then the influence of microcystin exposure on microRNAs expression was reviewed, and finally, the role of microRNAs in immune regulation was explored. Conclusions: Exposure to microcystin in vitro or in vivo can cause changes in the expression of miRNAs, as well as corresponding responses from the body's immune system. There has been evidence that miRNAs are involved in a variety of immune regulatory processes in the body, but there are still relatively few studies on the role of miRNAs in immune disorders caused by microcystins exposure. |
| Keywords: | Microcystin; miRNAs; Immune Disorder |
基金
| 1. | 安徽高校自然科学研究项目 (KJ2019A0229) |
| 2. | 安徽医学院王建华科研创新团队项目 (WJH2022004t) |
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