巨噬细胞自噬在肺部细菌性感染疾病中的作用及研究进展
宁夏医科大学基础医学院, 宁夏回族自治区常见传染病防治重点实验室, 宁夏银川 750004
| 摘 要： | 肺部感染性疾病是指由于病原微生物的入侵，导致终末气道、肺泡和肺间质发生的炎症。其中，肺部细菌性感染疾病是最常见的一种。而巨噬细胞自噬作为细胞内一种维持稳态的重要机制，在肺部细菌性感染疾病中具有重要的作用。如在肺结核疾病中，巨噬细胞自噬可以起到延缓进程，抵抗感染的作用；在细菌诱导的脓毒症引发的肺部损伤中，巨噬细胞自噬可以起到一定程度的保护作用。但巨噬细胞自噬在疾病中起到的作用并不都是有利的，在PVL阳性耐甲氧西林金黄色葡萄球菌以及铜绿假单胞菌诱导的肺部感染疾病中，巨噬细胞自噬起到了相反的作用。抗菌药物的出现和发展曾使肺部细菌性感染疾病的病死率有所下降，但近年来，即使应用着强力的药物以及有效的疫苗，其病死率并未进一步下降，甚至有所上升，如何降低其病死率成为了全球迫在眉睫的问题。本文综述了巨噬细胞自噬在肺部细菌性感染疾病中的作用及其研究进展，为进一步探索巨噬细胞自噬在肺部细菌性感染疾病治疗中的应用提供了理论基础。 |
| 关 键 词： | 巨噬细胞; 自噬; 肺部感染性疾病; 免疫调节 |
| DOI： | 10.57237/j.life.2024.03.001 |
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收稿日期: 2024-05-24
接受日期: 2024-07-10
在线出版日期: 2024-07-18
The Role of Macrophage Autophagy in Pulmonary Infectious Diseases and Research Progress
Key Laboratory for Prevention and Treatment of Common Infectious Diseases in Ningxia, School of Basic Medical Sciences, Ningxia Medical University, Yinchuan 750004, China
| Abstract: | Pulmonary infectious diseases refer to the inflammation of the terminal airway, alveoli and pulmonary interstitial due to the invasion of pathogenic microorganisms. Among them, bacterial infectious diseases in the lungs are the most common. Macrophage autophagy, as an important mechanism for maintaining homeostasis in cells, plays an important role in bacterial infectious diseases in the lungs. For example, in tuberculosis, macrophage autophagy can delay the process and resist infection; while in the process of lung damage caused by sepsis, macrophage autophagy can play a certain degree of protection. However, macrophage autophagy does not all play a beneficial role in diseases. In PVL-positive methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa-induced lung infections, macrophage autophagy plays the opposite role. Although the emergence and development of antibacterial drugs have reduced the mortality rate of bacterial infections in the lungs, in recent years, even with the application of powerful drugs and effective vaccines, the mortality rate has not declined further, or even increased. This paper reviews the role of macrophage autophagy in pulmonary bacterial infection and its research progress, and provides a theoretical basis for further exploring the application of macrophage autophagy in the treatment of pulmonary bacterial infection. |
| Keywords: | Macrophage; Autophagy; Pulmonary Infectious Diseases; Immune Regulation |
基金
| 1. | 宁夏回族自治区重点研发计划 (2021BEG03072) |
| 2. | 宁夏医科大学校级科研项目资助 (XM2020013) |
参考文献
| [1] | Lucas R, Hadizamani Y, Gonzales J, Gorshkov B, Bodmer T, Berthiaume Y, Moehrlen U, Lode H, Huwer H, Hudel M, Mraheil MA, Toque HAF, Chakraborty T, Hamacher J. Impact of Bacterial Toxins in the Lungs. Toxins (Basel). 2020 Apr 2; 12(4): 223. https://doi.org/10.3390/toxins12040223. PMID: 32252376; PMCID: PMC7232160. |
| [2] | Zha BS, Desvignes L, Fergus TJ, Cornelius A, Cheng TY, Moody DB, Ernst JD. Bacterial Strain-Dependent Dissociation of Cell Recruitment and Cell-to-Cell Spread in Early M. tuberculosis Infection. mBio. 2022 Jun 28; 13(3): e0133222. https://doi.org/10.1128/mbio.01332-22. Epub 2022 Jun 13. PMID: 35695454; PMCID: PMC9239178. |
| [3] | Misharin AV, Scott Budinger GR, Perlman H. The lung macrophage: a Jack of all trades. Am J Respir Crit Care Med. 2011 Sep 1; 184(5): 497-8. https://doi.org/10.1164/rccm.201107-1343ED. PMID: 21885631; PMCID: PMC3175549. |
| [4] | Hussell T, Bell TJ. Alveolar macrophages: plasticity in a tissue-specific context. Nat Rev Immunol. 2014 Feb; 14(2): 81-93. https://doi.org/10.1038/nri3600. Epub 2014 Jan 21. PMID: 24445666. |
| [5] | Lazarov T, Juarez-Carreño S, Cox N, Geissmann F. Physiology and diseases of tissue-resident macrophages. Nature. 2023 Jun; 618(7966): 698-707. https://doi.org/10.1038/s41586-023-06002-x. Epub 2023 Jun 21. Erratum in: Nature. 2023 Jul; 619(7970): E51. PMID: 37344646; PMCID: PMC10649266. |
| [6] | Yang Z, Klionsky DJ. Eaten alive: a history of macroautophagy. Nat Cell Biol. 2010 Sep; 12(9): 814-22. https://doi.org/10.1038/ncb0910-814. PMID: 20811353; PMCID: PMC3616322. |
| [7] | Yang Z, Klionsky DJ. Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol. 2010 Apr; 22(2): 124-31. https://doi.org/10.1016/j.ceb.2009.11.014. Epub 2009 Dec 23. PMID: 20034776; PMCID: PMC2854249. |
| [8] | Zhu Y, Tang Z, Huo S, Wu H, Wang L, Ding S. Regulatory relationship between macrophage autophagy and PVL-positive methicillin-resistant Staphylococcus aureus. Immunobiology. 2022 May; 227(3): 152223. https://doi.org/10.1016/j.imbio.2022.152223. Epub 2022 May 4. PMID: 35552111. |
| [9] | Pang Z, Xu Y, Zhu Q. Early Growth Response 1 Suppresses Macrophage Phagocytosis by Inhibiting NRF2 Activation Through Upregulation of Autophagy During Pseudomonas aeruginosa Infection. Front Cell Infect Microbiol. 2022 Jan 12; 11: 773665. https://doi.org/10.3389/fcimb.2021.773665. PMID: 35096638; PMCID: PMC8790152. |
| [10] | Zhang J, Liu C, Zhao G, Li M, Ma D, Meng Q, Tang W, Huang Q, Shi P, Li Y, Jiang L, Yu X, Zhu H, Chen G, Zhang X. PM2.5 Synergizes With Pseudomonas aeruginosa to Suppress Alveolar Macrophage Function in Mice Through the mTOR Pathway. Front Pharmacol. 2022 Jun 21; 13: 924242. https://doi.org/10.3389/fphar.2022.924242. PMID: 35800443; PMCID: PMC9253536. |
| [11] | Dong W, Wang G, Feng J, Li P, Wang R, Lu H, Lu W, Wang C, Wang X, Chen H, Xiang Y, Tan C. MiR-25 blunts autophagy and promotes the survival of Mycobacterium tuberculosis by regulating NPC1. iScience. 2022 Apr 22; 25(5): 104279. https://doi.org/10.1016/j.isci.2022.104279. PMID: 35586071; PMCID: PMC9108763. |
| [12] | Strong EJ, Wang J, Ng TW, Porcelli SA, Lee S. Mycobacterium tuberculosis PPE51 Inhibits Autophagy by Suppressing Toll-Like Receptor 2-Dependent Signaling. mBio. 2022 Jun 28; 13(3): e0297421. https://doi.org/10.1128/mbio.02974-21. Epub 2022 Apr 25. PMID: 35467412; PMCID: PMC9239179. |
| [13] | Distel JS, Di Venanzio G, Mackel JJ, Rosen DA, Feldman MF. Replicative Acinetobacter baumannii strains interfere with phagosomal maturation by modulating the vacuolar pH. bioRxiv [Preprint]. 2023 Feb 2: 2023.02.02.526753. https://doi.org/10.1101/2023.02.02.526753. Update in: PLoS Pathog. 2023 Jun 9; 19(6): e1011173. PMID: 36778331; PMCID: PMC9915592. |
| [14] | Zhu QJ, Wang J, Li Y, Bai ZJ, Guo XB, Pan T. PRKCA Promotes Mitophagy through the miR-15a-5p/PDK4 Axis to Relieve Sepsis-Induced Acute Lung Injury. Infect Immun. 2023 Jan 24; 91(1): e0046522. https://doi.org/10.1128/iai.00465-22. Epub 2022 Nov 30. PMID: 36448837; PMCID: PMC9872609. |
| [15] | Huang M, Yu Y, Tang X, Dong R, Li X, Li F, Jin Y, Gong S, Wang X, Zeng Z, Huang L, Yang H. 3-Hydroxybutyrate ameliorates sepsis-associated acute lung injury by promoting autophagy through the activation of GPR109α in macrophages. Biochem Pharmacol. 2023 Jul; 213: 115632. https://doi.org/10.1016/j.bcp.2023.115632. Epub 2023 May 31. PMID: 37263300. |
| [16] | Jiang F, Jiang J, He W, Dong G, Xu N, Meng L, Zhao Y, Wang M, Tan S, Shi Y, Li R. Chrysophanol alleviates acute lung injury caused by Klebsiella pneumoniae infection by inhibiting pro-inflammatory cytokine production. Phytother Res. 2023 Jul; 37(7): 2965-2978. https://doi.org/10.1002/ptr.7792. Epub 2023 Mar 6. PMID: 36879546. |
| [17] | Wu C, Guo L, Muhataer X, Li Q, Lian Z, Li Y, Wang W, Ding W, Zhou Y, Yang X, Chen M. Interaction between the PI3K/AKT pathway and mitochondrial autophagy in macrophages and the leukocyte count in rats with LPS-induced pulmonary infection. Open Life Sci. 2023 Apr 15; 18(1): 20220588. https://doi.org/10.1515/biol-2022-0588. PMID: 37077346; PMCID: PMC10106970. |
| [18] | Aceves-Sánchez MJ, Barrios-Payán JA, Segura-Cerda CA, Flores-Valdez MA, Mata-Espinosa D, Pedroza-Roldán C, Yadav R, Saini DK, de la Cruz MA, Ares MA, Bielefeldt-Ohmann H, Baay-Guzmán G, Vergne I, Velázquez-Fernández JB, Barba León J, Hernández-Pando R. BCG∆BCG1419c and BCG differ in induction of autophagy, c-di-GMP content, proteome, and progression of lung pathology in Mycobacterium tuberculosis HN878-infected male BALB/c mice. Vaccine. 2023 Jun 13; 41(26): 3824-3835. https://doi.org/10.1016/j.vaccine.2023.04.065. Epub 2023 May 8. PMID: 37164819. |
| [19] | Zhang J, Han L, Ma Q, Wang X, Yu J, Xu Y, Zhang X, Wu X, Deng G. RIP3 impedes Mycobacterium tuberculosis survival and promotes p62-mediated autophagy. Int Immunopharmacol. 2023 Feb; 115: 109696. https://doi.org/10.1016/j.intimp.2023.109696. Epub 2023 Jan 12. PMID: 36638666. |
