表观遗传学调控血管新生及其中医药干预
广西中医药大学, 赛恩斯新医药学院医学系, 广西南宁 530222
| 摘 要： | 血管新生指从现有血管系统生成新血管，在各组织器官发育和损伤修复中均有发生，主要依赖多种生长因子和缺氧诱导，在许多疾病发生发展复杂的分子机制中扮演重要角色，其中包括肿瘤、糖尿病、炎症、慢性肝病、心脏病和退行性眼病等，抑制或促进血管新生成为治疗这些疾病的潜在策略之一。表观遗传是指在不改变DNA序列的情况下，遗传信息通过某些机制或途径，发生可保存并传递给子代的基因表达或细胞表型的改变。近年来，表观遗传学在血管生成的研究中扮演着越来越重要的角色，参与了许多血管生成途径的正常调控和疾病相关的异常过程。本综述探讨表观遗传学如何影响血管生成的不同方面及其中医药干预治疗，以便更好地理解疾病发生和发展机制，为疾病的防治以及药物的研发提供新思路。 |
| 关 键 词： | 血管新生; DNA甲基化; 组蛋白修饰; m6A; 中医药 |
| DOI： | 10.57237/j.cmrd.2024.02.001 |
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收稿日期: 2024-06-14
接受日期: 2024-07-12
在线出版日期: 2024-07-29
Epigenetic Regulation of Angiogenesis and Its Intervention by Traditional Chinese Medicine
Department of Medicine, Faculty of Chinese Medicine Science, Guangxi University of Chinese Medicine, Nanning 530222, China
| Abstract: | Neovascularization refers to the generation of new blood vessels from the existing vascular system, which occurs in the development of various tissues and organs and in the repair of injuries, and is mainly dependent on a variety of growth factors and hypoxia-induced, and plays an important role in the complex molecular mechanisms of the development of many diseases, including tumors, diabetes mellitus, inflammation, chronic liver disease, cardiac disease, and degenerative eye disease, etc., and the inhibition or promotion of neovascularization has emerged as a potential strategy for the treatment of these diseases Inhibition or promotion of neovascularization is one of the potential strategies for the treatment of these diseases. Epigenetic inheritance refers to changes in gene expression or cellular phenotypes in which genetic information occurs through certain mechanisms or pathways that can be preserved and passed on to offspring without altering the DNA sequence. In recent years, epigenetics has played an increasingly important role in the study of angiogenesis and is involved in the normal regulation of many angiogenic pathways and disease-related abnormal processes. This review explores how epigenetics affects different aspects of angiogenesis and its treatment by Chinese medicine interventions, in order to better understand the mechanisms of disease onset and progression, and to provide new ideas for disease prevention and treatment as well as drug development. |
| Keywords: | Angiogenesis; DNA Methylation; Histone Modification; m6A; Chinese Medicine |
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