去氢吴茱萸碱的药理作用研究进展
桂林医学院附属医院, 肝胆胰外科, 广西桂林 541001
| 摘 要： | 去氢吴茱萸碱是一种中药单体，它通过从吴茱萸这味中药中分离提取来的，可以起到抑制炎症反应，减轻氧化应激的作用。去氢吴茱萸碱在神经系统具有抗遗忘作用；去氢吴茱萸碱能够减轻记忆功能障碍，机制也许是激活抗氧化应激和抑制脑组织Aβ的生成；去氢吴茱萸碱与乙酰胆碱酯酶结合是较为稳定的，有望成为治疗AD的潜在药物；去氢吴茱萸碱在心血管系统具有降低血压和减慢心率的作用；去氢吴茱萸碱在胃部疾病中具有保护胃黏膜，改善胃溃疡的作用；去氢吴茱萸碱能够减轻关节炎；去氢吴茱萸碱具有抗肿瘤的作用。也有研究显示去氢吴茱萸碱在肝脏有关疾病方面发挥一定的作用，具体机制不完全清楚。我们拟检索去氢吴茱萸碱相关文献，对去氢吴茱萸碱的对于相关疾病药理研究进展作一综述。 |
| 关 键 词： | 去氢吴茱萸碱; 药理作用; 研究进展 |
| DOI： | 10.57237/j.cmrd.2023.02.002 |
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收稿日期: 2022-12-11
接受日期: 2023-04-20
在线出版日期: 2023-04-25
Research Progress in Pharmacological Action of Dehydroevodiamine
Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical University, Guilin 541001, China
| Abstract: | Dehydroevodiamine is a traditional Chinese medicine monomer extracted from the herb Fructus officinalis, which can inhibit inflammation and reduce oxidative stress. Dehydroevodiamine has anti-amnesia effect in nervous system. Dehydroevodiamine can reduce memory dysfunction, perhaps by activating antioxidant stress and inhibiting the production of brain Aβ. The combination of acetylcholinesterase with dehydroevodiamine is relatively stable, which is expected to be a potential drug for the treatment of AD. In the cardiovascular system, dehydroevodiamine can lower blood pressure and slow down the heart rate. In gastric diseases, dehydroevodiamine has the effect of protecting gastric mucosa and improving gastric ulcer. dehydroevodiamine can reduce arthritis; dehydroevodiamine has antitumor effect. Some studies have also shown that dehydroevodiamine plays a role in liver-related diseases, but the mechanism is not completely clear. We intend to search the literature related to dehydroevodiamine officinalis and review the pharmacological research progress of dehydroevodiamine officinalis on related diseases. |
| Keywords: | Dehydroevodiamine; Pharmacological Effect; Research Progress |
基金
| 1. | 中国肝炎防治基金会天晴肝病研究基金 (TQGB20210052) |
| 2. | 广西壮族自治区卫生健康委员会自筹经费科研课题 (Z20200013, Z20200261) |
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