一例银杏内酯注射液致泛发性湿疹的案例分析
1. 四川省第二中医医院, 药剂科, 四川成都 610000
2. 成都市第三人民医院, 药剂科, 四川成都 610000
| 摘 要： | 目的：分析银杏内酯注射液致皮肤不良反应的临床特点，为其上市后安全性研究相关内容提供参考。方法：通过参与1例疑似银杏内酯注射液致皮肤不良反应的患者治疗过程，该患者因脑梗死给予银杏内酯注射液50mg静脉滴注、1次/d，连续2d，停药后6天，患者臀部出现皮疹，随后皮疹迅速扩散至全身，出现皮损伴有渗出倾向，皮肤瘙痒和广泛的表皮脱落，结合临床用药和此次不良反应的临床特点，从银杏内酯注射液的成分、银杏提取物的不良反应报道，分析银杏内酯注射液致皮肤不良反应的原因和机制。结果：经分析此次不良反应为银杏内酯注射液引起的严重皮肤过敏现象，在给予口服依巴斯汀、注射葡萄糖酸钙和维生素C、外用除湿止痒软膏治疗2周后，皮损基本愈合。结论：银杏内酯注射液引起的皮肤过敏性反应已有案例报道，但其安全性方面的临床试验研究仍缺乏药品上市后安全性研究相关内容，本次不良反应属于详细的个案分析，以期为银杏内酯注射液上市后安全性内容提供参考。 |
| 关 键 词： | 银杏内酯注射液; 泛发性湿疹; 严重药品不良反应 |
| DOI： | 10.57237/j.cmrd.2022.01.006 |
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收稿日期: 2022-11-01
接受日期: 2023-01-13
在线出版日期: 2023-02-03
A Case Study of Generalized Eczema Induced by Ginkgolide Injection
1. Pharmacy Department, Sichuan Second Hospital of T.C.M, Chengdu 610000, China
2. Pharmacy Department, Chengdu 610000, China
| Abstract: | Objective: To analyze the clinical characteristics of adverse skin reactions (ADRs) caused by ginkgolide injection, and to provide reference for the post-marketing safety study of ginkgolide injection. Methods: By participating in the treatment of a patient with suspected adverse skin reactions caused by ginkgolide injection, The patient was given target ginkgolide injection 50mg intravenously once a day for two consecutive days due to cerebral infarction. Six days after drug withdrawal, the patient developed a rash on the buttocks, and then the rash quickly spread to the whole body, resulting in skin lesions with exudation tendency, itchy skin and extensive epidermal shedding. Combined with clinical medication and the clinical characteristics of this adverse reaction, the causes and mechanisms of adverse reactions caused by ginkgolide injection were analyzed from the ingredients of ginkgolide injection and the adverse reaction reports of ginkgolide extract. Consults: The adverse reaction was analyzed as severe skin allergy caused by ginkgolide injection. After oral administration of ebastine, injection of calcium gluconate and vitamin C, and topical dehumidification and itching-relieving ointment, the skin lesions basically healed after 2 weeks. Conclusions: Cases of skin allergic reactions caused by ginkgolide injection have been reported, but clinical trials on the safety of ginkgolide injection still lack the content of post-marketing safety studies. This adverse reaction is a detailed case analysis, in order to provide reference for the content of post-marketing safety of ginkgolide injection. |
| Keywords: | Ginkgolide Injection; Generalized Eczema, Serious Adverse Drug Reactions |
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