Effect of Natural Functional Foods on Oxidative Stress and the Development of MASLD in HIV-Positive Individuals

Dachuan Jin; Shunqin Jin; Chunli Liu; Peng Gao; Guangming Li

doi:doi:10.57237/j.cmf.2025.01.001

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Abstract:	The effect of natural functional foods on oxidative stress in HIV-positive patients is summarized in this review, with particular attention to the implications for metabolic dysfunction-associated steatotic liver disease (MASLD). Since chronic liver disease, especially MASLD, is a prominent cause of death among HIV patients, the global prevalence of HIV continues to provide serious public health issues. Insulin resistance, lipid buildup, oxidative stress, and mitochondrial dysfunction are some of the many factors contributing to the pathophysiology of MASLD. In particular, oxidative stress interferes with regular cellular metabolism, resulting in fibrosis, inflammation, and hepatocellular cancer. Antioxidants have demonstrated promise in lowering oxidative stress and enhancing liver health. They can be found in various of functional foods, including salmon, pitaya, and specific plant-based and microbial sources. However, further research is needed to determine the precise therapeutic effects and mechanisms of action of these functional foods. Although there is encouraging evidence that antioxidant-active functional foods can help manage MASLD in persons living with HIV (PLWH), more thorough research is required to confirm their effectiveness and comprehend their underlying mechanisms.
Keywords:	Metabolic Dysfunction-Associated Steatotic Liver Disease; Oxidative Stress; Antioxidant; HIV; Functional Foods
DOI:	10.57237/j.cmf.2025.01.001

Effect of Natural Functional Foods on Oxidative Stress and the Development of MASLD in HIV-Positive Individuals

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