NLRP3炎症小体在子宫内膜异位症中的研究进展
大同市第一人民医院, 性激素大同市重点实验室, 山西大同大学性激素研究所, 山西大同 037009
| 摘 要： | 子宫内膜异位症（endometriosis, EMT）含义是除子宫体以外，其他部位生长子宫内膜组织（腺体和间质），是一种临床普遍的女性疾病。EMT患者常出现痛经、慢性盆腔痛、不孕、盆腔包块等临床症状，影响6%-10%育龄女性的生育能力、生活质量和健康状况，对女性生殖系统健康产生负面影响。炎症是调节EMT患者盆腔疼痛的重要因素，也是发展为慢性疼痛的风险因素。含氨基末端的吡喃结构域（PYD），中心核苷酸结合和齐聚结构域（NOD），C端富含亮氨酸重复序列结构域（LRR）各一个组成了NLRP3，可参与炎症小体的拼装，组成机体固有免疫系统。最近有研究发现NLRP3炎症小体通过促进促炎因子的大量产生分泌，增强异位内膜间质细胞的迁移侵袭能力，在子宫内膜异位症中扮演着重要角色。现对NLRP3炎症小体在子宫内膜异位症的研究情况进行综述，以期为子宫内膜异位症医治提供新的解法。 |
| 关 键 词： | NLRP3; 炎症小体; 子宫内膜异位症 |
| DOI： | 10.57237/j.cmf.2024.01.004 |
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收稿日期: 2023-12-28
接受日期: 2024-02-03
在线出版日期: 2024-02-04
Research Progress of NLRP3 Inflammasome in Endometriosis
nstitute of Gonadal Hormone Shanxi Datong University, Datong Key Laboratory of Sex Hormones, The First People's Hospital of Datong, Datong 037009, China
| Abstract: | Endometriosis (EMT) refers to the growth of endometrial tissue (glands and stroma) in other parts of the uterus than the body of the uterus. It is a common clinical disease of women. Patients with EMT often suffer from dysmenorrhea, chronic pelvic pain, infertility, pelvic mass and other clinical symptoms, which affect the fertility, quality of life and health status of 6%-10% of women of childbearing age, and have a negative impact on the health of female reproductive system. Inflammation is an important factor in regulating pelvic pain in patients with EMT and is a risk factor for developing chronic pain. NLRP3 is composed of amino terminal pyranoid domain (PYD), central nucleotide binding and oligomerization domain (NOD), and C-terminal leucine-rich repeat domain (LRR), which can participate in the assembly of inflammatory bodies and constitute the innate immune system. Recent studies have found that the NLRP3 inflammatome plays an important role in endometriosis by promoting the production and secretion of pro-inflammatory factors and enhancing the migration and invasion ability of ectopic endometrial stromal cells. This article reviews the research of NLRP3 inflammatome in endometriosis, in order to provide a new method for the treatment of endometriosis. |
| Keywords: | NLRP3; Inflammasome; Endometriosis |
基金
| 1. | 大同市应用基础研究计划项目 (基金号: 2022063) |
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