多种植物油组合在放化疗相关性皮肤粘膜毒性反应的治疗效果分析
1. 深圳市联科医疗科技有限公司, 广东深圳 518118
2. 南方医科大学深圳医院, 肿瘤科, 广东深圳 518101
| 摘 要： | 目的：描述多种植物油复方制剂在抗肿瘤治疗相关性急性皮肤、口腔粘膜毒性反应的治疗效果。方法：本观察性队列研究共入组37例肿瘤患者，所有均接受放疗和/或抗肿瘤药物治疗，且在治疗期间发生抗肿瘤治疗相关皮肤粘膜毒性反应。患者接受多种植物油复方制剂的治疗，利用常⻅不良事件评价标准（CTCAE5.0）评价皮肤粘膜毒性反应的分级及恢复状况。结果：患者的中位年龄51.5岁，男性26例（70.3%）。单纯放疗8例（21.6%），单纯药物治疗14例（37.8%）；放化疗联合治疗15例（40.5%）。头颈部癌15例（40.5%）、胃肠道肿瘤13例（35.1%），乳腺癌6例（16.2%），其他肿瘤3例（8.1%）。3度放射性皮炎3例，2度放射性皮炎11例；3度口腔粘膜炎7例，2度口腔粘膜炎5例，1度口腔粘膜炎8例；3度手足综合征3例，2度手足综合征5例。多种植物油复方制剂治疗抗肿瘤相关性皮炎的中位恢复时间为5天，口腔粘膜炎的中位恢复时间为5-10天，手足综合征的恢复时间为8-10天。结论：复方植物油制剂对中重度抗肿瘤治疗相关性皮肤或/和粘膜毒性反应治疗有效性较好，中位恢复时间为5-10天，患者耐受性好。 |
| 关 键 词： | 肿瘤; 植物油; 放射治疗; 药物治疗; 毒性反应 |
| DOI： | 10.57237/j.cmf.2023.04.002 |
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收稿日期: 2023-09-08
接受日期: 2023-10-27
在线出版日期: 2023-10-28
The Primary Response of Multiple Plant Oils Combination in the Treatment of Chemoradiotherapy Related Toxicities
Department of Oncology, Shenzhen Hospital of Southern Medical University, Shenzhen 518101, China
| Abstract: | Objective: To report the primary response to chemoradiotherapy induced dermatitis and/or oral mucositis. Methods: In this prospective cohort, 37 patients who underwent concurrently or sequentially chemotherapy and/or anti-cancer drug therapy received personalized multiple plant oil treatment when they suffered the dermatitis and/or oral mucositis. The grade of toxicities and the recovery was evaluated with the criteria of Common Terminology Criteria for Adverse Events (CTCAE) 5.0. Results: For all the patients, the median age was 51.5 and the male was 26 patients (70.3%). 14 (37.8%) and 8 (21.6%) patients respectively received chemotherapy and radiotherapy alone, and 15 (40.5%) had chemoradiotherapy. Head and neck, gastrointestinal, breast and the other cancer were 15 (40.5%), 13 (35.1%), 15 (40.5%), 6 (16.2%) and 3 (8.1%) respectively. Three and 11 patients suffered grade 3 and 2 radiation induced dermatitis respectively. Seven, five and seven patients did grade 3, 2 and 1 of oral mucositis respectively. Three and five patients had grade 3 and 2 of hand and foot syndrome. For dermatitis, oral mucositis, hand and foot syndrome, the median recovery time was 5, 5-10 and 8-10 days. Conclusion: For patients suffering from the chemoradiotherapy induced skin and/or mucosal toxicities, the multiple plant oils could be effective. All the patients tolerate well and the median recovery time were 5-10 days. |
| Keywords: | Tumor; Plant Oils; Radiotherapy; Anti-cancer Drug Therapy; Toxicity |
基金
| 1. | 国家自然科学基金 (81974462) |
| 2. | 南方医科大学深圳医院临床研究启动计划 (LCJH202003) |
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