中国西南地区女性人乳头瘤病毒感染状况和宫颈病变的关系探讨
1. 昆明医科大学第一附属医院, 生殖遗传科/妇科, 云南昆明 650032
2. 云南省阜外心血管医院, 检验科, 云南昆明 650032
3. 大理州人民医院, 检验科, 云南大理 671000
| 摘 要： | 目的：分析中国西南地区女性人乳头瘤病毒(HPV)的感染状况，并探讨感染不同亚型、宫颈病变程度及患者年龄间之间的相关性，为宫颈癌早期诊断和预防提供参考依据。方法：收集昆明医科大学第一附属医院行阴道镜检查的1543例女性为研究对象，分析其HPV感染状况、基因亚型及年龄分布特征。分析HPV各亚型感染及不同年龄组HPV感染与宫颈病变的关系。结果：1543例标本中检出HPV阳性率为86.78%。检出HPV亚型48种，感染率前5位的亚型为HPV16、18、52、58及33。各年龄段感染HPV的宫颈组织病理学结果之间差异有统计学意义(P＜0.05)。HPV感染女性的宫颈癌性病变多发生在50岁以上，宫颈组织病理学结果中各年龄段感染HPV占比呈“n”型分布。各年龄段HPV感染以多重感染型别(66.25%)及三重及以上感染(39.51%)为主。高危型感染随年龄增加而下降，低危型感染随年龄增加而升高，各组HPV感染组高危亚型明显高于低危亚型，高危亚型以16、18、52型为主。宫颈癌组HPV亚型为高危亚型，以16、18亚型为主。结论：中国西南地区宫颈癌高发人群中HPV流行亚型为16、18、52；年龄是影响HPV感染亚型及宫颈组织病理学结果的重要因素，尤其需要重视50岁以上，感染亚型16、18女性患者的宫颈癌性病变筛查和防护，降低宫颈癌的发病率。 |
| 关 键 词： | 人乳头瘤病毒; 感染亚型; 宫颈上皮内瘤变; 年龄; 相关性 |
| DOI： | 10.57237/j.cmf.2022.01.002 |
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收稿日期: 2022-09-22
接受日期: 2022-10-29
在线出版日期: 2022-11-01
Relationships Between HPV Infection and Cervical Lesions in Women from Southwest China
1. Department of Genetics and Reproduction/Gynecology, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
2. Department of Laboratory Medicine, Yunnan Fuwai Cardiovascular Hospital, Kunming 650032, China
3. Department of Laboratory Medicine, People's Hospital of Dali, Dali 671000, China
| Abstract: | Objective: To analyze the infection status of human papillomavirus (HPV) in women from Southwest China and explore the correlation between different subtypes of HPV infection, the degree of cervical lesions and the age of patients, to provide reference for the early diagnosis and prevention of cervical cancer. Methods: The data of 1543 women from the department gynecology of the first affiliated hospital of Kunming medical university for colposcopy were enrolled in this study and the data were analyzed here. According to the cervical pathological results, women infecting HPV were divided into cervical intraepithelial neoplasia grade I group, cervical intraepithelial neoplasia grade II group, cervical intraepithelial neoplasia grade III group and cervical cancer group, cervicitis group. Results: 1339 cases (86.78%) were infected with HPV among 1543 specimens. Forty-eight HPV subtypes were detected, and the top five infection rates were HPV16, 18, 52, 58 and 33. Statistical difference between cervical pathology results between age group and HPV infection were detected at P<0.05. Most cervical cancer lesions of HPV-infected women were over 50 years old. In addition, except for the cervical cancer group, and the proportion of HPV infection in each age group showed an "n" type distribution pattern in cervical pathology results. The majority patients with HPV infection were multiple infection (66.25%) and triple or more types of HPV infection (39.51%). The proportion of high-risk subtypes of HPV infection decreased gradually with the increase of age, while the proportion of low-risk subtypes increased with the increase of age. The high-risk subtype was significantly higher than the low-risk subtype in the cervical pathological HPV infection subtypes in each group, and the most high-risk subtypes were 16, 18 and 52. The HPV subtypes in the cervical cancer group were only high-risk subtypes, and subtypes 16 and 18 showed the highest frequency. Conclusions: The main types of HPV in Kunming were HPV subtypes 16, 18 and 52. Age was an important factor influencing the subtype of HPV infection as well as cervical pathology outcomes. To reduce clinical cervical cancer lesions, attention should be paid to the screening and protection of cervical cancer lesions in women aged more than 50 years old with HPV infection of HPV subtypes 16 and 18. |
| Keywords: | Human Papillomavirus; Subtype of Infection; Cervical Intraepithelial Neoplasia; Age; Correlation |
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