Cervical Cancer in Case with Pelvic Organ Prolapse (POP) and Stress Urinary Incontinence (SUI)
Department of Gynecology, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
| Abstract: | Background: Combined cervical cancer and pelvic organ prolapse (POP) is extremely uncommon and there is no standard treatment guideline for the complex comorbidity. We attempted to provide a treatment strategy and explore possible reasons for the comorbidities. Case presentation: We presented a 62-year-old patient seeking treatment for postmenopausal tissue prolapse and leakage of urine. The gynecologic examination revealed the uterine prolapse with a 2.5 cm papillary and erosive lesion on the cervix that was pathologically confirmed as cervical squamous cell carcinoma in stage Ib1. Clinical diagnosis included cervical squamous cell carcinoma in stage Ib1, prolapse of uterus and vagina, stress urinary incontinence (SUI). Then she was performed radical surgery for cervical cancer and tension-free vaginal tape-obturator (TVT-O). The urine function was good after operation. The surgery solved two diseases, which improved the quality of life (QOL) of patient and radically cured cervical carcinoma at the same time. Follow up for more than two years, HPV was negative, no prolapse symptoms occurred, and the quality of life was good. Conclusions: Surgical-based treatment seems to be more suitable that can cure the two diseases and improve the QOL. We should pay attention to the potential high incidence of HPV infection and HPV-related cervical cancer so that we should not ignore the screening for cervical cancer in the prolapse group and initiate surgery treatment strategies of cervical cancer or pre-cancerous lesions as early as possible to reach an optimal outcome of patient. |
| Keywords: | Pelvic Organ Prolapse (POP); Stress Urinary Incontinence (SUI); Cervical Cancer; Surgery-Based Treatment; Tension-Free Vaginal Tape-Obturator (TVT-O); Quality of Life (QOL); Human Papillomavirus (HPV) Infection |
| DOI: | 10.57237/j.wjcm.2023.01.002 |
View:
Downloads:
Received: 7 January 2023
Accepted: 28 February 2023
Published Online: 2 March 2023
References
| [1] | Chen WQ, Zheng RS, Baade PD, et al. Cancer Statistics in China, 2015. Ca Cancer J Clin. 2016; 66 (2): 115-132. |
| [2] | Venkatas J, Singh M. Cervical cancer. a meta-analysis, therapy and future of nanomedicine. Ecancer medical science. 2020; 24; 14: 1111. |
| [3] | Wu JM, Vaughan CP, Goode PS et al. Prevalence and trends of symptomatic pelvic floor disorders in U.S. women. Obstet Gynecol. 2014; 123: 141-148. |
| [4] | Matsuo K, Fullerton ME, Moeini A. Treatment patterns and survival outcomes in patients with cervical cancer complicated by complete uterine prolapse: a systematic review of literature. Int Urogynecol J. 2016; 27: 29-38. |
| [5] | Bowden SJ, Bodinier B, Kalliala I, et al. Genetic variation in cervical preinvasive and invasive disease: a genome-wide association study. Lancet Oncol. 2021 Apr; 22 (4): 548-557. |
| [6] | Bump RC, Mattiasson A, Bø K, Brubaker LP, et al. The standardization of terminology of female pelvic organ prolapse and pelvic floor dysfunction. Am J Obstet Gynecol. 1996 Jul; 175 (1): 10-7. |
| [7] | Clabaut M, Suet A, Racine PJ, et al. Effect of 17β-estradiol on a human vaginal Lactobacillus crispatus strain. Sci Rep. 2021; 11 (1): 7133. |
| [8] | Bugge C, Adams EJ, Gopinath D, et al. Pessaries (mechanical devices) for managing pelvic organ prolapse in women. Cochrane Database Syst Rev. 2020; 18; 11: CD004010. |
| [9] | Abu-Rustum NR, Yashar CM, Bean S et al. NCCN Guidelines Insights: Cervical Cancer, Version 1.2020. J Natl Compr Canc Netw. 2020; 18 (6): 660-666. |
| [10] | American College of Obstetricians and Gynecologists' Committee on Practice Bulletins—Gynecology and American Urogynecologic Society. Pelvic Organ Prolapse: ACOG Practice Bulletin, Number 214. Obstet Gynecol. 2019; 134 (5): e126-e142. |
| [11] | NICE Guidance - Urinary incontinence and pelvic organ prolapse in women: management: © NICE (2019) Urinary incontinence and pelvic organ prolapse in women: management. BJU Int. 2019; 123 (5): 777-803. |
| [12] | Dawkins JC, Lewis GK, Toy EP. Cervical cancer complicating pelvic organ prolapse, and use of a pessary to restore anatomy for optimal radiation: A case report. Gynecol Oncol Rep. 2018; 16; 26: 14-16. |
| [13] | Pardal C, Correia C, Serrano P. Carcinoma of the cervix complicating a genital prolapse. BMJ Case Rep. 2015; 2015: bcr2015209580. |
| [14] | Chung CP, Lee SJ, Wakabayashi MT. Uterine and cervical cancer with irreducible pelvic organ prolapse. Am J Obstet Gynecol. 2018; 219 (6) 621–622. |
| [15] | Ota Y, Suzuki Y, Matsunaga T, et al. New combined surgery for cervical cancer complicated by pelvic organ prolapse using autologous fascia lata: A case report. Clin Case Rep. 2020; 20; 8 (8): 1382-1386. |
| [16] | El-Abbassi S, El-Majjaoui S, El-Kacemi H, et al. Complete genital prolapse with cervix carcinoma: a case report and literature review. Arch Can Res. 2017; 5: 2. |
| [17] | Kahn RM, Gordhandas S, Craig K, et al. Cervical carcinoma in the setting of uterovaginal prolapse: comparing standard versus tailored management. Ecancer medical science. 2020; 14: 1043. |
Join the Editorial Board
We invite active, qualified and high profile scientists and researchers to join as Editorial Board Members.
Join UsBecome a Reviewer
Scholars with a strong interest in reviewing are invited to join the reviewer panel to ensure the quality of the research to be published.
Join Us