To Explore the Mechanism of Salvia Miltiorrhiza in Preventing Liver Fibrosis Based on Angiogenesis
1. Department of Physiology, School of Basic Medicine, Guangxi University of Chinese Medicine, Nanning 530222, China
2. Department of Medicine, Faculty of Chinese Medicine Science, Guangxi University of Chinese Medicine, Nanning 530222, China
| Abstract: | Objective: Network pharmacology and molecular docking were used to explore the mechanism of Salvia miltiorrhiza in the prevention and treatment of liver fibrosis based on angiogenesis. Method: The active pharmacological components and their action targets of Salvia miltiorrhiza were clarified by TCMSP database, and the targets related to hepatic fibrosis and angiogenesis were obtained by TTD, GeneCards, CTD and other databases. The active components of Salvia miltiorrhiza and the targets related to liver fibrosis and angiogenesis were interactively processed by Venn map. The drug-component-target-disease network was constructed by Cytoscape3.9.0 software, and the interaction target network was constructed by using String database. The interaction targets were analyzed by GO (Gene Ontology) enrichment analysis and KEGG (Kyoto Encyclopedia of Genesand Genomes) signal pathway analysis using Metascape platform to clarify the molecular mechanism of Salvia miltiorrhiza in the prevention and treatment of liver fibrosis based on angiogenesis. Result: 65 active components and 132potential targets of Salvia miltiorrhiza were screened from TCSMP database, 4841 and 1200 targets of hepatic fibrosis and angiogenesis were screened by GeneCards, TTD and CTD database respectively, 50 common targets of Salvia miltiorrhiza affecting angiogenesis and prevention and treatment of liver fibrosis were obtained by mapping, and the Salvia miltiorrhiza-component-target-disease network map was constructed. The common target proteins were analyzed by PPI network, and the key targets were obtained. The enrichment analysis of GO and KEGG signal pathways on the Metascape platform showed that PI3K-Akt signal pathway, AGE-RAGE signal pathway in diabetic complications, MAPK signal pathway, VEGF signal pathway and other signal pathways may be involved in different aspects of Salvia miltiorrhiza regulating angiogenesis and preventing liver fibrosis. The results of molecular docking are good. Conclusion: A variety of main active components of Salvia miltiorrhiza play the role of anti-angiogenesis through multiple pathways, so as to prevent and treat liver fibrosis. |
| Keywords: | Liver Fibrosis; Angiogenesis; Salvia; Network Pharmacology |
| DOI: | 10.57237/j.mrf.2023.04.006 |
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Received: 7 November 2023
Accepted: 6 December 2023
Published Online: 27 December 2023
Funding
| 1. | 国家自然科学基金项目 (82204755, 81960751) |
| 2. | 广西自然科学基金青年基金项目 (2023GXNSFBA297094) |
| 3. | 广西中医药大学赛恩斯新医药学院国家级大学生创新创业训练项目 (202313643012) |
| 4. | 广西中医药大学国家级大学生创新创业训练项目 (202310600020) |
| 5. | 广西中医药大学青年基金项目 (2022QN008; 2022MS024) |
| 6. | 广西中医药大学赛恩斯新医药学院科研项目 (2022MS002; 2022MS008; 2022QJ001) |
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