Key Issues and Novel Strategies of Stem Cell Intervention and Decellularized Scaffold Liver Tissue Engineer for End-Stage Liver Disease
1. Hepatobiliary Institute, Southwest Hospital, Army Medical University, Chongqing 400038, China
2. Department of Orthopaedics, Pinking University Third Hospital, Beijing 100191, China
| Abstract: | End-stage liver disease (ESLD) is ultimation of all kinds of chronic liver diseases. It is highly morbidity and mortality disease and currently no effective treatment is available. Liver transplantation (LTx) is the only way for the treatment. However, the organ source limitation interferes with clinical application of LTx. For the goal of crossing liver source shortage barrier, researches attempt to explore techniques or methods like stem cells and tissue engineering, and recent years sounds developed rapidly and bright prospects, for example, artificial liver, tissue-engineered liver and xenotransplantation etc., in particular adult stem cells like bone marrow-derived mesenchymal stem cells (BMMSCs) and decellularized liver scaffold for large scale liver tissue engineer seems more eye-catching, and such decellularization / recellularization technology used has become the first strategy to build complex organs. We have previously discussed some points in the |
| Keywords: | Tissue Engineering; End-Stage Liver Disease; Liver Transplantation; Stem Cells; Decellularized Liver Scaffold; Bilinary Epithelial Cells; Hepatic Sinusoid |
| DOI: | 10.57237/j.mrf.2023.01.003 |
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Received: 9 December 2022
Accepted: 9 February 2023
Published Online: 16 February 2023
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