The Meta-analysis of HPV Infection in Patients with Oral Squamous Cell Carcinoma
(Hebei Key Laboratory for Chronic Diseases), North China University of Science and Technology, Tangshan 063210, China
| Abstract: | Objective: To comprehensively evaluate the association between Oral Squamous Cell Carcinoma (OSCC) and Human Papillomavirus (HPV) infection by Meta analysis. Methods: Using oral squamous cell carcinoma and human papillomavirus as search terms, full-text English literatures in PubMed and Web of Science were searched, and the collected data were analyzed statistically by using Review Manager and Stata MP 17.0. To investigate the etiological association between oral squamous cell carcinoma and human papillomavirus infection. Results: A total of 13 literatures were included according to the screening criteria, including 1026 patients with oral squamous cell carcinoma and 966 patients in the control group. Random effects model was used for meta-analysis based on heterogeneity test results. The results showed that the average HPV positive rate of patients with oral squamous cell carcinoma worldwide was 31.48%, OR: 3.58, 95%CI: 1. 98~6.50, Z test results showed a z value of 4.20, P<0.05, which indicated that the occurrence of oral squamous cell carcinoma is correlated with HPV. Subgroup analysis showed that gender, lymph node metastasis, degree of tumor differentiation, tumor grade, tumor site, and personal lifestyle (smoking and alcohol consumption) were not significantly associated with HPV infection in patients with oral squamous cell carcinoma, while location of patients was associated with HPV Infection. Publication bias estimation and sensitivity analysis showed no significant publication bias. Conclusion: Through a Meta analysis of HPV infection in patients with oral squamous cell carcinoma worldwide, it was found that the location of patients with oral squamous cell carcinoma was associated with HPV infection. |
| Keywords: | Human Papillomavirus; Oral Squamous Cell Carcinoma; Meta-analysis |
| DOI: | 10.57237/j.life.2024.01.001 |
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Received: 7 December 2023
Accepted: 28 December 2023
Published Online: 20 January 2024
Funding
| 1. | 河北省自然基金生物医药联合基金培育项目 (No. H2022209049) |
References
| [1] | Hübbers C U, Akgül B. HPV and cancer of the oral cavity [J]. Virulence, 2015, 6(3): 244-8. |
| [2] | 李亚楠, 梁辉. 人乳头瘤病毒相关口咽鳞状细胞癌发生机制的研究进展 [J]. 山东大学耳鼻喉眼学报: 1-8. |
| [3] | Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J]. Ca-a Cancer Journal for Clinicians, 2018, 68(6): 394-424. |
| [4] | 黄碧莹, 张强. 尼古丁在口腔癌发生、发展中的作用机制及研究进展 [J]. 口腔颌面外科杂志, 2023, 33(01): 46-8. |
| [5] | 郭治辰, 荆思理, 虎小毅, 等. 吸烟饮酒对不同年龄OSCC患者预后的影响 [J]. 口腔医学, 2022, 42(06): 521-4. |
| [6] | 臧希言, 王君蓉, 刘东旭, 等. HPV感染在口腔鳞癌中的研究进展 [J]. 现代肿瘤医学, 2023, 31(10): 1952-6. |
| [7] | Sun Y, Zhang Y, Liu L M, et al. Genetic polymorphisms and HPV infection in oral squamous cell carcinomas [J]. Current Opinion in Virology, 2015, 14: 1-6. |
| [8] | Luo C W, Roan C H, Liu C J. Human papillomaviruses in oral squamous cell carcinoma and pre-cancerous lesions detected by PCR-based gene-chip array [J]. International Journal of Oral and Maxillofacial Surgery, 2007, 36(2): 153-8. |
| [9] | Purwanto D J, Soedarsono N, Reuwpassa J O, et al. The prevalence of oral high-risk HPV infection in Indonesian oral squamous cell carcinoma patients [J]. Oral Dis, 2020, 26(1): 72-80. |
| [10] | Chang J Y-F, Lin M-C, Chiang C-P. High-Risk Human Papillomaviruses May Have an Important Role in Non–Oral Habits–Associated Oral Squamous Cell Carcinomas in Taiwan [J]. American Journal of Clinical Pathology, 2003, 120(6): 909-16. |
| [11] | Hallikeri K, Burde K, Anehosur V, et al. p53 polymorphism and association of human papillomavirus in oral submucous fibrosis and oral squamous cell carcinoma: A case-control study [J]. J Oral Maxillofac Pathol, 2019, 23(1): 97-103. |
| [12] | Gan L L, Zhang H, Guo J H, et al. Prevalence of human papillomavirus infection in oral squamous cell carcinoma: a case-control study in Wuhan, China [J]. Asian Pac J Cancer Prev, 2014, 15(14): 5861-5. |
| [13] | Sugiyama M, Bhawal U K, Dohmen T, et al. Detection of human papillomavirus-16 and HPV-18 DNA in normal, dysplastic, and malignant oral epithelium [J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2003, 95(5): 594-600. |
| [14] | Ashraf M J, Hosseini S, Monabati A, et al. The Prevalence of Human Papilloma Virus in Squamous Cell Carcinoma of Oral Tongue [J]. Iran J Pathol, 2017, 12(2): 144-9. |
| [15] | Zhang Z Y, Sdek P, Cao J, et al. Human papillomavirus type 16 and 18 DNA in oral squamous cell carcinoma and normal mucosa [J]. Int J Oral Maxillofac Surg, 2004, 33(1): 71-4. |
| [16] | Gonzalez-Ramirez I, Irigoyen-Camacho M E, Ramirez-Amador V, et al. Association between age and high-risk human papilloma virus in Mexican oral cancer patients [J]. Oral Dis, 2013, 19(8): 796-804. |
| [17] | Lohavanichbutr P, Houck J, Fan W, et al. Genomewide gene expression profiles of HPV-positive and HPV-negative oropharyngeal cancer: potential implications for treatment choices [J]. Arch Otolaryngol Head Neck Surg, 2009, 135(2): 180-8. |
| [18] | Kansky A A, Poljak M, Seme K, et al. Human papillomavirus DNA in oral squamous cell carcinomas and normal oral mucosa [J]. Acta Virol, 2003, 47(1): 11-6. |
| [19] | Szarka K, Tar I, Feher E, et al. Progressive increase of human papillomavirus carriage rates in potentially malignant and malignant oral disorders with increasing malignant potential [J]. Oral Microbiol Immunol, 2009, 24(4): 314-8. |
| [20] | Elango K J, Suresh A, Erode E M, et al. Role of human papilloma virus in oral tongue squamous cell carcinoma [J]. Asian Pac J Cancer Prev, 2011, 12(4): 889-96. |
| [21] | Rahman R, Shaikh M H, Gopinath D, et al. Human papillomavirus and Epstein-Barr virus co-infection in oral and oropharyngeal squamous cell carcinomas: A systematic review and meta-analysis [J]. Mol Oral Microbiol, 2023. |
| [22] | Qian L, Qian B, Xu J, et al. Clinical relevance of serum lipids in the carcinogenesis of oral squamous cell carcinoma [J]. BMC Oral Health, 2023, 23(1): 200. |
| [23] | Montero P H, Patel S G. Cancer of the oral cavity [J]. Surg Oncol Clin N Am, 2015, 24(3): 491-508. |
| [24] | Khurshid Z, Zafar M S, Khan R S, et al. Role of Salivary Biomarkers in Oral Cancer Detection [J]. Adv Clin Chem, 2018, 86: 23-70. |
| [25] | Howard A, Agrawal N, Gooi Z. Lip and Oral Cavity Squamous Cell Carcinoma [J]. Hematol Oncol Clin North Am, 2021, 35(5): 895-911. |
| [26] | Rettig E M, D'Souza G. Epidemiology of head and neck cancer [J]. Surg Oncol Clin N Am, 2015, 24(3): 379-96. |
| [27] | 赵睿娟, 李正霞, 张芳芳.口腔鳞状细胞癌患者首次根治性手术治疗后的生存情况及其影响因素分析 [J]. 实用癌症杂志, 2022, 37(09): 1554-6. |
| [28] | Campisi G, Giovannelli L, Calvino F, et al. HPV infection in relation to OSCC histological grading and TNM stage. Evaluation by traditional statistics and fuzzy logic model [J]. Oral Oncology, 2006, 42(6): 638-45. |
| [29] | Chi A C, Day T A, Neville B W. Oral cavity and oropharyngeal squamous cell carcinoma--an update [J]. CA Cancer J Clin, 2015, 65(5): 401-21. |
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