Research on the Interaction between AP and Herring Sperm DNA
Ningbo Oceanographic Center, Ministry of Natural Resources, Ningbo 315175, China
| Abstract: | Deoxyribonucleic acid (DNA) is one of the important living substances and a carrier of genetic information in organisms. In medical research, the study of the mechanism of the interaction between targeted molecules and DNA is of great significance for elucidating the effects of some anti-tumor, antiviral drugs, and carcinogens. It can further guide the synthesis of artificial nucleic acids, advanced DNA structures, and the design and synthesis of new drugs. UV and fluorescence spectroscopic methods to study the mechanism of action of the small molecule drugs with herring sperm DNA. Determine the interaction of drugs and DNA single-stranded and double-stranded way. The interaction between AP and DNA may be realized via groove combined. The thermodynamic formulation constant (K) was ca. 105 mol-1.L. By studying the interaction between AP, a small molecule drug, and DNA, a new approach has been provided to explore the potential mechanisms of DNA damage and inheritance at the molecular level. |
| Keywords: | UV; FS; AP; Herring Sperm DNA; Interaction Mode |
| DOI: | 10.57237/j.life.2023.03.003 |
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Received: 9 July 2023
Accepted: 31 August 2023
Published Online: 8 September 2023
Funding
| 1. | 自然资源部东海局青年科技基金项目 (202209) |
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