Clinical Study on Ultrasound-guided Acupuncture Combined with Ozone Intra-articular Injection for the Treatment of Knee Osteoarthritis
1. Department of Anesthesiology, Ruijin Hospital Lu Wan Branch, Shanghai Jiao Tong University School of Medicine, Shanghai 200020, China
2. Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
| Abstract: | Objective To evaluate the efficacy of acupuncture combined with intra-articular ozone injection in treating of knee osteoarthritis (KOA). Methods: 90 patients with KOA, 43 males and 47 females, aged 45 ~ 70 years, with BMI of 20.5 ~ 27.9 kg/m2, were selected. They were randomly divided into control group (Group C) and treatment group (group T), with 45 cases in each group. Group C: intra-articular injection of ozone; Group T: acupuncture combined with intra-articular ozone injection. Ozone treatment was performed once a week for 4 weeks; Acupuncture was performed once a day, six times a week, for 4 weeks. Record the score results of VAS/WOMAC pre-treatment, 1st, 5th, 12th, 24th, 48th weeks post-treatment. SF-36 scores were recorded pre-treatment and 24th and 48th weeks post-treatment. Results In both groups, post-treatment VAS scores at 1st, 5th, 12th, 24th, 48th week showed a significant reduction compared to pre-treatment scores (p < 0.001). The VAS score at post-treatment 1st week was significantly lower in the treatment group compared to the control group (p < 0.001), but there was no significant difference between two groups starting from 5th to 48th week visit (p > 0.05). The WOMAC pain, stiffness, physical function, and total score indicated a significant reduction when compared to pre-treatment (p < 0.001). The WOMAC pain, stiffness, physical function was better in group T compared to the group C at the 1st week (p < 0.001), but there was no significant difference between two groups starting from 5th to 48th week visit group (p > 0.05). Conclusion Acupuncture combined with intra-articular injection of ozone is better than intra-articular injection of ozone alone, with better pain control and faster improvement of joint function. |
| Keywords: | Acupuncture; Ozone; Intra-articular Injection; Knee Osteoarthritis |
| DOI: | 10.57237/j.cmrd.2024.04.001 |
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Received: 23 September 2024
Accepted: 19 November 2024
Published Online: 23 December 2024
Funding
| 1. | 上海市黄浦区科研项目 (HLM202106) |
| 2. | 嘉定区农业和社会事业科研项目 (JDKW-2019-W11) |
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