Research Progress in Pharmacological Action of Dehydroevodiamine
Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical University, Guilin 541001, China
| Abstract: | Dehydroevodiamine is a traditional Chinese medicine monomer extracted from the herb Fructus officinalis, which can inhibit inflammation and reduce oxidative stress. Dehydroevodiamine has anti-amnesia effect in nervous system. Dehydroevodiamine can reduce memory dysfunction, perhaps by activating antioxidant stress and inhibiting the production of brain Aβ. The combination of acetylcholinesterase with dehydroevodiamine is relatively stable, which is expected to be a potential drug for the treatment of AD. In the cardiovascular system, dehydroevodiamine can lower blood pressure and slow down the heart rate. In gastric diseases, dehydroevodiamine has the effect of protecting gastric mucosa and improving gastric ulcer. dehydroevodiamine can reduce arthritis; dehydroevodiamine has antitumor effect. Some studies have also shown that dehydroevodiamine plays a role in liver-related diseases, but the mechanism is not completely clear. We intend to search the literature related to dehydroevodiamine officinalis and review the pharmacological research progress of dehydroevodiamine officinalis on related diseases. |
| Keywords: | Dehydroevodiamine; Pharmacological Effect; Research Progress |
| DOI: | 10.57237/j.cmrd.2023.02.002 |
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Received: 11 December 2022
Accepted: 20 April 2023
Published Online: 25 April 2023
Funding
| 1. | 中国肝炎防治基金会天晴肝病研究基金 (TQGB20210052) |
| 2. | 广西壮族自治区卫生健康委员会自筹经费科研课题 (Z20200013, Z20200261) |
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