Multiple Proliferating Trichilemmal Tumor with Positive Family History: A Case Report and Review of the Literature
1. Department of Dermatology, The Third Hospital of Mianyang (Sichuan Mental Health Center), Mianyang 621000, China
2. Department of Pathology, The Third Hospital of Mianyang (Sichuan Mental Health Center), Mianyang 621000, China
| Abstract: | Objective: Proliferating trichilemmal tumor is uncommon tumors that develop from the hair follicle's outer root sheath. They frequently correspond to the transition of a simple trichilemmal cyst, and they typically occur on the scalp of elderly women. However, multiple proliferating trichilemmal tumor are more rare and difficult to diagnose. Therefore, the diagnosis and treatment of this disease were discussed based on the relevant literature and the clinical data of multiple proliferating trichilemmal tumor in our hospital. Methods: The clinical data of a 74 year old female patient with multiple proliferating trichilemmal tumor and positive family history admitted to department of dermatology were retrospectively analyzed, combined with relevant literature review and discussion. Results: After surgical radical treatment, it is suggested to be multiple proliferating trichilemmal tumor based on the pathological result and immunohistochemical results. Conclusion: Proliferating trichilemmal tumors a rare but morphologically distinctive tumor. The diagnosis is mainly based on pathological results. Based on the histopathologic findings of tumor, this case was diagnosed as proliferating trichilemmal tumor. Surgery is the first choice for treatment. The patient’s condition was successfully treated with total excision. Regular postoperative review is required. Proliferating trichilemmal tumor need to be diagnosed and treated using a multidisciplinary strategy. Close clinical follow-up is the most efficient method of early metastasis and recurrence detection. |
| Keywords: | Multiple Proliferating Trichilemmal Tumor; Pathology; Immunohistochemistry; Surgery; Diagnosis and Treatment |
| DOI: | 10.57237/j.cmf.2023.02.002 |
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Received: 16 July 2023
Accepted: 15 September 2023
Published Online: 19 September 2023
References
| [1] | Osto M, Parry N, Rehman R, et al. Malignant Proliferating Trichilemmal Tumor of the Scalp: A Systematic Review. Am J Dermatopathol. 2021; 43(12): 851-866. |
| [2] | Azizi M, Ramezani M. Malignant proliferating trichilemmal tumor in abdominal wall: Report of a rare case at an uncommon site with literature review. Clin Case Rep. 2022; 10(1): e05259. |
| [3] | Çoban K, Akkaya H, Aydın E. Proliferating Trichilemmal Tumor of the Auricula: A Very Rare Locus. Indian J Otolaryngol Head Neck Surg. 2019; 71(Suppl 2): 1436-1438. |
| [4] | Karaca S, Kulac M, Dilek FH, et al. Giant proliferating trichilemmal tumor of the gluteal region. Dermatol Surg. 2005; 31(12): 1734-1736. |
| [5] | Chaichamnan K, Satayasoontorn K, Puttanupaab S, et al. Malignant proliferating trichilemmal tumors with CD34 expression. J Med Assoc Thai. 2010; 93(Suppl 6): S28-34. |
| [6] | Wang X, Yang J, Yang W. Multiple proliferating trichilemmal tumors in a middle-aged yellow man. Tumori. 2010; 96(2): 349-351. |
| [7] | Alici O, Keles MK, Kurt A, et al. A Rare Cutaneous Adnexal Tumor: Malignant Proliferating Trichilemmal Tumor. Case Rep Med. 2015; 5(4): 742920. |
| [8] | Wu M, Liao C, Zhao Z, et al. Local narrow margin excision sequential with modified ALA-PDT for successful treatment of an 86-year-old patient with malignant proliferating trichilemmal tumor. Photodiagnosis Photodyn Ther. 2023; 23(42): 103524. |
| [9] | Morgado B, Agostini P, Rivero A, et al. Extensive and ulcerated malignant proliferating trichilemmal (pilar) tumour, arising from multiple, large, degenerated trichilemmal (pilar) cysts. BMJ Case Rep. 2016; 2(8): 209785. |
| [10] | Lee DY, Han KM, Yoon JS. A malignant proliferating trichilemmal cyst arising on the elbow of a man: A case report and review of the literature. Medicine. 2023; 102(25): e34035. |
| [11] | Agarwal C, Pujani M, Raychaudhuri S, et al. Squamous Cell Carcinoma versus Malignant Proliferating Trichilemmal Tumor: A Histopathological Dilemma with Review of Literature. Indian J Dermatol. 2019; 64(4): 339. |
| [12] | Rangel-Gamboa L, Reyes-Castro M, Dominguez-Cherit J, et al. Proliferating trichilemmal cyst: the value of ki67 immunostaining. Int J Trichology. 2013; 5(3): 115-117. |
| [13] | Ye J, Nappi O, Swanson PE, et al. Proliferating pilar tumors: a clinicopathologic study of 76 cases with a proposal for definition of benign and malignant variants. Am J Clin Pathol. 2004; 122(4): 566-574. |
| [14] | Cavanagh G, Negbenebor NA, Robinson-Bostom L, et al.. Two Cases of Malignant Proliferating Trichilemmal Tumor (MPTT) and Review of Literature. R I Med J (2013). 2022; 105(1): 12-16. |
| [15] | Rosmaninho A, Caetano M, Oliveira A, et al. Proliferating trichilemmal tumor of the nose. An Bras Dermatol. 2012; 87(6): 914-916. |
| [16] | Kearns-Turcotte S, Thériault M, Blouin MM. Malignant proliferating trichilemmal tumors arising in patients with multiple trichilemmal cysts: A case series. JAAD Case Rep. 2022; 17(22): 42-46. |
| [17] | Kemaloğlu CA, Öztürk M, Aydın B, et al. Malignant proliferating trichilemmal tumor of the scalp: report of 4 cases and a short review of the literature. Case Reports Plast Surg Hand Surg; 2022; 9(1): 158-164. |
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