Relationships Between HPV Infection and Cervical Lesions in Women from Southwest China
1. Department of Genetics and Reproduction/Gynecology, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China
2. Department of Laboratory Medicine, Yunnan Fuwai Cardiovascular Hospital, Kunming 650032, China
3. Department of Laboratory Medicine, People's Hospital of Dali, Dali 671000, China
| Abstract: | Objective: To analyze the infection status of human papillomavirus (HPV) in women from Southwest China and explore the correlation between different subtypes of HPV infection, the degree of cervical lesions and the age of patients, to provide reference for the early diagnosis and prevention of cervical cancer. Methods: The data of 1543 women from the department gynecology of the first affiliated hospital of Kunming medical university for colposcopy were enrolled in this study and the data were analyzed here. According to the cervical pathological results, women infecting HPV were divided into cervical intraepithelial neoplasia grade I group, cervical intraepithelial neoplasia grade II group, cervical intraepithelial neoplasia grade III group and cervical cancer group, cervicitis group. Results: 1339 cases (86.78%) were infected with HPV among 1543 specimens. Forty-eight HPV subtypes were detected, and the top five infection rates were HPV16, 18, 52, 58 and 33. Statistical difference between cervical pathology results between age group and HPV infection were detected at P<0.05. Most cervical cancer lesions of HPV-infected women were over 50 years old. In addition, except for the cervical cancer group, and the proportion of HPV infection in each age group showed an "n" type distribution pattern in cervical pathology results. The majority patients with HPV infection were multiple infection (66.25%) and triple or more types of HPV infection (39.51%). The proportion of high-risk subtypes of HPV infection decreased gradually with the increase of age, while the proportion of low-risk subtypes increased with the increase of age. The high-risk subtype was significantly higher than the low-risk subtype in the cervical pathological HPV infection subtypes in each group, and the most high-risk subtypes were 16, 18 and 52. The HPV subtypes in the cervical cancer group were only high-risk subtypes, and subtypes 16 and 18 showed the highest frequency. Conclusions: The main types of HPV in Kunming were HPV subtypes 16, 18 and 52. Age was an important factor influencing the subtype of HPV infection as well as cervical pathology outcomes. To reduce clinical cervical cancer lesions, attention should be paid to the screening and protection of cervical cancer lesions in women aged more than 50 years old with HPV infection of HPV subtypes 16 and 18. |
| Keywords: | Human Papillomavirus; Subtype of Infection; Cervical Intraepithelial Neoplasia; Age; Correlation |
| DOI: | 10.57237/j.cmf.2022.01.002 |
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Received: 22 September 2022
Accepted: 29 October 2022
Published Online: 1 November 2022
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